Engineering encapsulation materials and methods to preserve organoids and biopsy material

我们正在寻找一名积极进取的学生进行一项多学科项目，以解决如何保存3D细胞和组织的问题，使医院和实验室能够进行个性化的医学研究。人们越来越认识到，新鲜的临床样本或3D有机化合物是宝贵的资源，使研究人员能够探索癌症等疾病的个性化治疗方法。该项目将在学术环境中工作，但与生物技术公司Atelerix合作，探索他们围绕细胞封装https://www.atelerix.co.uk/的技术，以及如何针对3D有机物和活检材料进行优化。个性化医学要求实验室和医院共享珍贵的生长细胞和活组织的样本，但运输可能会带来一些问题，包括费用、细胞活性和原始表型的保存。这个博士项目将探索最佳细胞保存所需的关键生物物理参数，以保持细胞、有机体和组织在运输过程中的存活，以提高我们进行研究的能力，包括围绕个性化药物的研究。

We are seeking a highly motivated student to undertake a multidisciplinary project to solve the problem of how to preserve 3D cell and tissues to enable hospitals and laboratories to undertake personalize medicine studies. Increasingly, it is appreciated that fresh clinical samples or 3D organoids are valuable resources that enable researchers to explore personalized treatments for diseases such as cancers. This project will work in an academic setting, but in collaboration with the biotech company Atelerix to explore their technology around cell encapsulation https://www.atelerix.co.uk/ and how this might be optimized for 3D organoids and biopsy material. Personalised medicine requires that laboratories and hospitals share samples of precious growing cells and living tissues, but the shipment can present problems, including expense, cell viability and preservation of original phenotype. This PhD project will explore the key biophysical parameters needed for optimal cell preservation to keep cells, organoids and tissues viable during transit to improve our capabilities to perform research, including around personalized medicine.