UCLA SPORE IN PROSTATE CANCER

描述（由申请人提供） 一个校园范围内的前列腺癌研究计划已经制定， 加州大学洛杉矶分校的多所学校和研究所的合作。前列腺癌 程序区最近已被命名为一个完整的程序区的琼森 综合癌症中心（JCCC）。这个程序提供了基础 对于这个应用程序。SPORE的目的是，沿着其他 孢子机构，以促进诊断的进展， 预防和治疗前列腺癌。SPORE项目有两个主要的 目标： 1.发展多种转化型基础研究和基于社区的 重点关注少数民族人口的研究项目。四种实验室 研究项目将应用有关基因表达的机构研究， 前列腺癌的治疗和预后一个项目将 利用机构调查人员的经验， 前列腺癌的饮食控制方面。 2.开发新的前列腺癌研究和职业发展，以推进 翻译研究这将通过现有和持续的 机构支持以及职业发展方案和发展 研究项目。 所有研究项目的重点是快速转化为临床试验。 现有的临床研究计划已经协调，以提供最好的 所有阶段的前列腺癌患者的研究。的 四个基础研究项目是相互联系的，因为它们a）显然是 可翻译，B）基于个体研究者的 c）提供新的战略， 前列腺癌的早期症状这些信息 研究还提供了预后信息，并将增加目前的 局限性前列腺癌预后的临床和分子标志物。 外部咨询委员会将参与监督和分析 在所有研究和行政领域取得进展。合作 有了JCCC，SPORE代表了一个主要的跨学科，协作， 和翻译计划，承诺作出重大影响， 前列腺癌死亡率和发病率。

DESCRIPTION (provided by applicant) A campus-wide Prostate Cancer Research Program has been developed with collaboration of multiple schools and institutes at UCLA. The Prostate Cancer Program area has recently been named a full Program Area of the Jonsson Comprehensive Cancer Center (JCCC). This germinal program provides the basis for this SPORE application. The purpose of the SPORE is, along with other SPORE institutions, to contribute to the progress in the diagnosis, prevention, and treatment of prostate cancer. The SPORE project has two major objectives: 1. To develop multiple translational basic research and community-based research projects with an emphasis on minority populations. Four laboratory research projects will apply institutional research on gene expression and signaling, to prognosis and treatment of prostate cancer. One project will build on the experience of institutional investigators to address innovative aspects of dietary control of prostate cancer. 2. To develop new prostate cancer research and career development to advance translational research. This will be effected through existing and continued institutional support as well as career development programs and developmental research programs. The emphasis in all research projects is rapid translation to clinical trials. Existing clinical research programs have been coordinated to provide the best possible access to study patients with all stages of prostate cancer. The four basic research projects are linked, in that they a) are clearly translatable, b) are based on basic work within the individual investigator's own laboratories, and c) provide new strategies for targeting specific signaling pathways important in prostate cancer. Information from these studies also provides prognostic information and will add to the current clinical and molecular markers of prognosis for localized prostate cancer. An external Advisory Board will participate in the supervision and analysis of SPORE progress in all research and administrative areas. In collaboration with the JCCC, the SPORE represents a major interdisciplinary, collaborative, and translational program which promises to make a significant impact on prostate cancer mortality and morbidity.