Regulation type I and II interferon in CD180 regulated B cells and their role in Lupus pathogenesis

该项目的目的是了解如何CD 180调节B细胞有助于狼疮的发病机制。我们假设CD 180可能起到抑制B细胞中干扰素信号传导的作用，并且在SLE中下调可能促进TLR 7和/或其他干扰素调节的蛋白表达。为了解决这个问题，第一步将是验证I型和II型干扰素刺激在B细胞中的作用。接下来，我们将研究B细胞中CD 180和干扰素之间的相互作用。最后，将研究狼疮鼠模型中B细胞的CD 180阳性和阴性亚群之间的差异。

The aim of this project is to understand how CD180 regulated B cells contribute to pathogenesis in lupus. We hypothesise that CD180 may function to dampen interferon signalling in B cells and that is downregulation in SLE may promote TLR7 and/or other interferon regulated protein expression. To address this the first step will be to characterise the effect of type I and II interferon stimulation in B cells. Next, we will examine the interplay between CD180 and interferon in B cells. Finally, investigation will be carried out into the difference between CD180 positive and negative subpopulations of B cells in lupus murine models.