INFORMATICS TRAINING FOR BRAZILIAN VECTOR AND PARASITIC*

描述（由申请人提供）：本提案代表了乔治亚大学、乔治华盛顿大学、里约热内卢奥斯瓦尔多·克鲁兹-FIOCRUZ研究所和巴西贝洛奥里藏特雷内·拉丘-FIOCRUZ研究中心的研究人员之间的合作培训伙伴关系。CPqRR目前有15个实验室和3个资助的NIH拨款（一项关于新发和再发疾病的培训拨款，一项关于血吸虫病宿主遗传相关的ICIDR拨款，以及一项关于巴西农村心脏病遗传结构的拨款）。该培训计划的目标是在CPqRR生物信息学、流行病学和分子进化领域建立一个可持续的核心基础设施，以补充现有的NIH资助研究并促进在其他实验室进行的研究。CPqRR的研究重点是热带寄生虫、它们的媒介和宿主。这些生物包括：恶性疟原虫、克氏锥虫、刚地弓形虫、曼氏血吸虫、按蚊、生物phalaria和人类。该提案旨在通过启动一个为期5年的目标培训计划来满足CPqRR的需求，该计划涉及来自CPqRR 15个实验室中的许多实验室的博士生和博士后。高级培训将在巴西国内外通过讲习班、课程、短期和长期培训进行。培训将涉及合作研究项目，这些项目源于《血吸虫病防治计划》的需要，并侧重于血吸虫病的几个方面。这次培训的统一项目将是创建一个血吸虫基因组关系数据库，该数据库由CPqRR存储和服务。该数据库将容纳CPqRR生成的转录组数据和流行病学数据。分子进化培训将侧重于血吸虫病媒，生物phalaria和流行病学/生物统计学数据将从现有资助项目中获得和分析。从这次培训和实施中获得的技术和知识将直接适用于对其他寄生生物的研究。我们将积极寻找合格的培训候选人，他们有强烈的回国愿望，并将他们新获得的专业知识贡献给当地卓越培训中心的延续。

DESCRIPTION (provided by applicant): This proposal represents a collaborative training partnership between researchers at the University of Georgia, the George Washington University, the Instituto Oswaldo Cruz-FIOCRUZ in Rio de Janeiro and the Centro de Pesquisas Rene Rachou - FIOCRUZ in Belo Horizonte, Brazil. The CPqRR currently has 15 laboratories and 3 funded NIH grants (A training grant in emerging and re-emerging diseases, an ICIDR grant on host genetic correlates in schistosomiasis and a grant on the genetic architecture of heart disease in rural Brazil". The goal of this training proposal is to establish a sustainable core infrastructure at the CPqRR in the areas of bioinformatics, epidemiology and molecular evolution that will complement existing NIH funded research and facilitate research conducted in other laboratories. The focus of research at the CPqRR is tropical parasites, their vectors and their hosts. These organisms include: Plasmodium falciparum, Trypanosoma cruzi, Toxoplasma gondii, Schistosoma mansoni, Anopheles, Biomphalaria and Humans. This proposal is designed to meet the needs of the CPqRR by initiating a 5-year targeted training program that involves pre-and post-doctoral students from many of the 15 laboratories at the CPqRR. Advanced training will be conducted via workshops, courses, short- and long-term training both within Brazil and abroad. Training will involve collaborative research projects originating from the needs of the CPqRR and focusing on several aspects of schistosomiasis. The unifying project for this training will be the creation of a Schistosoma genome relational database housed and served from the CPqRR. This database will house the transcriptome data and epidemiological data being generated by the CPqRR. Molecular evolution training will focus on the Schistosome vector, Biomphalaria and epidemiological/ biostatistical data will be derived and analyzed from existing funded projects. The technology and knowledge acquired from this training and implementation exercise will be directly applicable to research on other parasitic organisms. We will proactively seek out well qualified candidates for training that have a strong desire to return and contribute their newly acquired expertise to the continuation of a local training center of excellence.