Mid-Career Investigator Award in Eating and Weight

这个应用程序是在面向患者的研究K-24职业中期奖。候选人Carlos M. Grilo博士是耶鲁大学医学院精神病学副教授，他是饮食失调项目的主任。格里洛博士在以患者为导向的饮食/体重失调研究方面有着良好的记录，在暴食症（BED）方面有着特殊的专业知识。格里洛博士有指导受训者/教员进行病人研究的记录，并接受了三次少数民族培训补充。Grilo博士目前担任NIDDK R01授权的PI，研究肥胖BED患者的不同治疗方法。该研究测试了认知行为疗法（CBT）、行为减肥（BWL）和序列CBT-BWL，这是K-24时期的一个主要项目，并进行了详细描述。Grilo博士目前担任Donaghue基金会资助的PI，负责测试针对肥胖/BED的不同指导自助行为治疗，以及美国心脏协会资助的一项随机安慰剂对照试验，该试验是针对肥胖/BED的肥胖药物与CBT同时给予的。此前，格里洛博士以PI的身份获得了NIDDK R29资助，用于一项随机安慰剂对照比较试验，测试BED的心理和药物治疗方法，并获得了NIMH R03资助，用于神经性贪食症的对照药物试验。Grilo博士曾担任多个基金会和NIH资助的联合研究员。预计未来将继续积极支持研究，特别是如果授予K-24以确保免受临床管理职责的保护时间。

This application is for a K-24 Mid-Career Award in Patient-Oriented Research. The candidate, Carlos M. Grilo, Ph.D., is Associate Professor of Psychiatry at the Yale School of Medicine, where he serves as Director of the Eating Disorder Program. Dr. Grilo has an established record of patient-oriented research in eating/weight disorders, with specific expertise in binge eating disorder (BED). Dr. Grilo has a track record of mentoring trainees/faculty in patient research and has received three Minority-Training Supplements. Dr. Grilo currently serves as PI on a NIDDK R01 grant examining different treatments for obese BED patients. The study tests cognitive behavioral therapy (CBT), behavioral weight loss (BWL), and sequenced CBT-BWL, is one major project for the K-24 period, and is described in detail. Dr. Grilo currently serves as PI on a Donaghue Foundation grant testing different guided self-help behavioral treatments for obesity/BED and an American Heart Association grant for a randomized placebo-controlled trial of an obesity medication given concurrently with CBT for obesity/BED. Dr. Grilo previously received, as PI, a NIDDK R29 grant for a randomized placebo-controlled comparative trial testing psychological and pharmacological treatments for BED, and a NIMH R03 for a controlled pharmacologic trial for bulimia nervosa. Dr. Grilo has served as Co-Investigator on several Foundation and NIH grants. Maintaining active support for research in the future is anticipated, particularly if K-24 is awarded to ensure protected time from clinical-administrative duties. The K-24 will allow Dr. Grilo to maintain a research focus on eating/weight disorders. To increase his contributions addressing these major public health problems, the K-24 will allow him to further enhance his effectiveness as an investigator/mentor. Internationally recognized consultants have been secured. Dr. has recruited strong postdoctoral fellows and is well positioned to mentor them and faculty. Funded programs provide unique resources for training the next generation of clinical-researchers of eating/weight disorders