Shedding of HIV In Semen Despite Antiretroviral Therapy

描述(由申请人提供)：这是匹兹堡大学医学院和公共卫生研究生院医学、流行病学、传染病和微生物学副教授Lee H.Harrison医学博士职业生涯中期奖(K24)的申请书。此应用程序的目标是使应聘者能够大幅改变其职业方向，并更加重视指导初级教师、博士生和对从事以患者为导向的研究事业感兴趣的传染病研究员。具体地说，这个K24奖项将允许哈里森博士：1)为医学院的传染病研究员和初级教员、公共卫生研究生院的博士生和来自巴西的初级调查人员提供以患者为导向的研究指导；2)与候选人指导的初级教员合作，开展一项研究，以确定在接受高效抗逆转录病毒治疗的艾滋病毒感染者中，精液中艾滋病毒RNA持续脱落的因素；3)建立候选人最近在匹兹堡大学建立的传染病流行病学研究部的研究。该股的重点是巴西艾滋病毒感染的流行病学和预防，以及疫苗可预防和抗药性侵袭性细菌感染的流行病学、分子流行病学和预防。候选人在这两个研究领域都有成功的发表和指导记录。这一奖项将允许哈里森博士在他指导的各种研究项目中大幅改变他的日常角色。保护时间的增加将导致研究生产率的提高，特别是因为它将为匹兹堡大学指导下一代以患者为导向的调查人员提供保护时间。

DESCRIPTION (provided by applicant): This is an application for a Midcareer Award for Patient-Oriented Research (K24) for Lee H. Harrison, M.D., Associate Professor of Medicine, Epidemiology, and Infectious Diseases and Microbiology at the University of Pittsburgh School of Medicine and Graduate School of Public Health. The goal of this application is to allow the candidate to substantially change the direction of his career, with an increased emphasis on mentoring junior faculty, doctoral students, and infectious diseases fellows interested in pursuing careers in patient-oriented research. Specifically, this K24 award will allow Dr. Harrison to: 1) provide mentoring in patient-oriented research to infectious diseases fellows and junior faculty in the School of Medicine, doctoral students in the Graduate School of Public Health, and junior investigators from Brazil, 2) in collaboration with a junior faculty member mentored by the candidate, conduct a study to identify factors for persistent shedding of HIV RNA in semen among HIV-infected persons taking highly-active antiretroviral therapy, 3) build the research of the Infectious Diseases Epidemiology Research Unit, which the candidate recently established at the University of Pittsburgh. The focus of the unit is the epidemiology and prevention of HIV infection in Brazil and the epidemiology, molecular epidemiology, and prevention of vaccine-preventable and drug-resistant invasive bacterial infections. The candidate has a successful track record of publication and mentoring in both of these areas of research. This award will allow Dr. Harrison to substantially change his day-to-day role on a variety of research projects he directs. The increase in protected time will lead to an increase in research productivity particularly because it will provide protected time for mentoring the next generation of patient-oriented investigators at the University of Pittsburgh.