Developing Research Capacity in Africa for Studies on HIV-Associated Malignancies

描述（由申请人提供）：基利曼哈罗基督教医学中心（KCMC）和杜克大学医学中心（DUMC）将合作进一步发展艾滋病毒相关恶性肿瘤的研究能力。KCMC位于坦桑尼亚的莫希，该地区受到艾滋病毒感染和相关并发症的严重影响，包括宫颈癌、卡波西肉瘤、淋巴瘤和结膜鳞状细胞癌等肿瘤。KCMC和DUMC有非常成功的现有合作，得到了NIH的慷慨支持，并参与现有的合作研究网络。这种支持为临床研究的开展创造了强大的科学基础设施，并通过福格蒂国际中心的培训赠款进一步加强。这些努力的主要重点是艾滋病毒/艾滋病及其传染性并发症，拟议的培训和研究方案将在很大程度上建立在这些初步投资的基础上。KCMC和DUMC对扩大肿瘤学研究的兴趣越来越大，特别是HIV相关的恶性肿瘤。然而，为了实现这一目标，解决KCMC研究环境中的缺点至关重要，这是拟议培训计划领导层最近调查的主题。临床和实验室研究方法、病理学、放射学和研究支持人员（如肿瘤科护士、药剂师、实验室技术人员和数据管理人员）的培训对于成功参与癌症相关研究至关重要。KCMC-DUMC计划将提供精心设计的长期，中期和短期培训组合，以解决本提案中概述的具体缺点。这些培训的地点将包括在南北和南南地点提供的正式学位和非学位实习课程。共有35名研究者和研究人员将在该计划的3年期间接受培训。他们的培训经验将得到补充的机会，从事网络赞助的和制药商发起的艾滋病毒相关的恶性肿瘤的研究，从而结合教学与扩大研究实践。在3年的合作结束时，KCMC-DUMC将准备开始扩大肿瘤学研究议程。

DESCRIPTION (provided by applicant): The Kilimanjaro Christian Medical Centre (KCMC) and Duke University Medical Center (DUMC) will partner to further develop research capacity in HIV-associated malignancies. KCMC is located in Moshi, Tanzania, an area significantly impacted upon by HIV infection and associated complications, including neoplasms such as cervical cancer, Kaposi's sarcoma, lymphoma and squamous cell carcinoma of the conjunctiva. KCMC and DUMC have highly successful existing collaborations that have received generous NIH support, and participate in existing collaborative research networks. This support has created a robust scientific infrastructure for the conduct of clinical investigation, which is further enhanced with training grants from the Fogarty International Center. The major focus of these efforts has been on HIV/AIDS and its infectious complications, and the proposed training and research program will build substantially on these initial investments. There is increasing interest at KCMC and DUMC in expanding research in oncology, especially HIV-associated malignancies. However, to achieve this goal it is critical to address shortcomings in the research environment at KCMC, the subject of a recent investigation by the proposed training program leadership. Training in clinical and laboratory research methodology, pathology, radiology, and research support staff such as oncology nurses, pharmacists, laboratory technologists and data managers will be critical to engage successfully in cancer-related research. The KCMC-DUMC program will offer a carefully designed portfolio of long, medium and short-term trainings to address the specific shortcomings outlined in this proposal. The venues for these trainings will include a mix of formal degree and non-degree practicum programs, offered in North-South and South-South locations. A total of 35 investigators and research staff will be trained during the 3 years of this program. Their training experiences will be complemented by opportunities to engage in network-sponsored and investigator-initiated research into HIV-associated malignancies, thereby combining didactic learning with expanding research practices. At the completion of 3 years the KCMC-DUMC collaboration will be prepared to embark on an expanded oncology research agenda.