Wits Non-communicable Disease Research Leadership Program

描述（由申请人提供）：需要在发展中国家的非传染性疾病的综合研究培训计划已经出现了需要了解的性质，程度和速度的过渡到新出现的疾病的生活方式。培训的重点将是心血管和代谢疾病（肥胖症和2型糖尿病）。具体目标是制定一个培训计划，并在硕士，博士和博士后水平，跨越学科和提供能力，以解决大问题训练有素的研究人员组。这些疾病在南部非洲的流行程度如何？我们如何监测和了解根本原因？我们可以制定哪些有效的干预方案？该研究培训计划将嵌入区域，国家和国际研究框架。它与动员科学界应对不断变化的疾病和残疾负担，特别是非传染性疾病的负担的福格蒂目标相一致;它将通过为卫生科学家提供可持续培训，发展人的能力，以应对挑战;它将在发展中国家促进可持续的研究环境。这将是一个综合计划，将确保从基础和临床科学中产生和传播知识，以告知公共卫生问题，包括社会和文化考虑。它的目的是采取一种转化的办法，将反馈到人口保健政策中。这项培训将通过整合和合作，在威特沃特斯兰德大学的几个既定的研究计划，包括索韦托心脏研究，阿金库尔农村设施和出生到二十研究，了解流行病学，遗传风险因素，机制和社区干预的机会的目的。从发展中国家征聘的受训人员将从全球角度深入了解非传染性疾病的原因及其对健康的影响。 公共卫生相关性：发展中国家的经济和文化转型正在导致非传染性疾病的负担日益加重。对流行病学以及社会、遗传和环境原因的透彻理解将导致发展中国家采取创新和负担得起的干预措施和治疗方法。

DESCRIPTION (provided by applicant): The need for an integrated Research Training Program in non-communicable diseases in developing countries has arisen out of the need to understand the nature, extent and pace of the transition to the emerging diseases of lifestyle. The emphasis in training will be on cardiovascular and metabolic diseases (obesity and type 2 diabetes). The specific aim is to develop a Training Program and a group of well trained researchers at the Masters, PhD and post-doctoral levels that cut across disciplines and provide capacity to tackle the big questions. What is the prevalence of these diseases in southern Africa? How can we monitor and understand the underlying causes? What effective intervention programs could we develop? This Research Training Program will be embedded in a regional, national and international research framework. It is aligned with the Fogarty Goals of mobilizing the scientific community to address the shifting burden of disease and disability specifically in non-communicable diseases; it will develop human capacity to meet the challenges by providing sustainable training for health scientists; and it will foster a sustainable research environment in a developing country. It will be an integrated Program that will ensure knowledge generation and dissemination from the basic and clinical sciences to inform public health issues, including social and cultural considerations. It is aimed at a translational approach that will feed back into population health policy. This training will be enabled through the integration and collaboration across several established research programs at the University of the Witwatersrand, including the Soweto Heart Study, the Agincourt Rural Facility and the Birth to Twenty Study, with the aim of understanding the epidemiology, the genetic risk factors, the mechanisms and opportunities for community intervention. Trainees recruited from developing countries will obtain a global insight into the causes and impact of non-communicable diseases on health. PUBLIC HEALTH RELEVANCE: Economic and cultural transition in developing nations is causing a shift to the increasing burden of non communicable diseases. A thorough understanding of the epidemiology and the social, genetic and environmental causes will lead to innovative and affordable interventions and treatments in developing countries.