Phase II Construction of NCNPR Research Wing

项目描述（由申请人提供）：该项目的目标是完成密西西比大学国家天然产物研究中心（NCNPR）二期研究中心的建设。这将需要增加顶部两层，并完成该研究翼一楼的一部分，总共约55,000平方英尺的新研究空间。请注意，已经为地下室的建设和一楼的基本完工投入了资金；该项目预计于2009年秋季开始，预计于2011年初完成。根据NCNPR最初的规划和第二期设施规划文件的设想，本申请申请资金用于建造第二期研究翼的第二层和第三层，以及为完成第一层而进行的部分扩建。这个拟议的项目，如果获得批准，可以安排时间，以便与目前资助的部分作为一个单一的、连续的建设一起完成。这个NCNPR项目的基础是一些PHS和其他联邦资助的研究项目，旨在发现、设计和合成新药，以及开发新的药物输送系统，以满足人类健康方面未满足的治疗需求，这是一个重要的国家优先事项。促进这些技术商业化的早期开发活动也将是该计划的关键功能。这些努力是实现这些基于自然产品的发现的全部潜在经济影响的关键组成部分。此外，NCNPR有一个强大的和不断增长的研究努力，以扩大科学基础，以加强认证，质量和安全的植物产品在美国用作膳食补充剂。按计划完成这一建设将促进基础研究转化为临床研究和商业开发，具体如下：1)为大规模提取和分离天然产品提供实验室，以支持先进的开发活动；2)为放大合成和模拟开发提供实验室；3)提供符合良好实验室规范的分析设备，支持生物分析研究、产品和监管包装的开发；4)为原料药（API）的生产提供符合gmp要求的设施；5)为原料药的预配制、配方和稳定性研究提供实验室；6)为细胞和分子作用机制及毒性研究提供实验室；7)提供实验室以扩大对微生物和海洋天然产物的研究。申请的资金将支持建设，包括55,127总平方英尺（部分一楼，7,117；二楼，24,005；三楼，24,005）。一楼部分将包括4个实验室，约860平方英尺，二楼和三楼各有8个实验室；每层楼还包括实验室和建筑/机械支持区以及办公室/隔间/会议空间。用这笔申请的资金在三层楼建造的净实验室、办公和支持空间总计为23,011平方英尺的新实验室空间，9,773平方英尺的新办公空间，以及15,460平方英尺的支持区域。

DESCRIPTION (provided by applicant): The objective of this project is the completion of the construction of the University of Mississippi's National Center for Natural Products Research (NCNPR) Phase II research wing. This will entail addition of the top two floors, with completion of a portion of the first floor of this research wing, with a total of about 55,000 gross SF of new research space. Note that funds are already committed for the construction of the basement and substantial completion of the first floor; this is slated to begin in fall 2009, with an anticipated completion date in early 2011. This application requests funds to construct the second and third floors, and partial build-out for completion of the first floor, of the Phase II research wing as envisioned in the original NCNPR planning and in the Phase II facility programming document. This proposed project, if awarded, can be timed so as to be completed in concert with the currently funded component as a single, continuous construction. At the foundation of this NCNPR program are a number of PHS and other federally funded research projects aimed at discovery, design, and synthesis of new drugs and development of new drug delivery systems for unmet therapeutic needs in human health, an important national priority. Early development activities to facilitate commercialization of these technologies will also be a critical function for this program. Such efforts are key components for realization of the full potential economic impact of these natural product-based discoveries. In addition, the NCNPR has a strong and growing research effort to expand the scientific basis for enhancement of the authentication, quality and safety of botanical products used as dietary supplements in the US. Completion of this construction as planned will foster translation of basic research into clinical studies and commercial development as follows: 1) provide laboratories for scaling up extraction and isolation of bulk natural products in quantities that will support advanced development activities; 2) provide laboratories for scale-up synthesis and analog development; 3) provide Good Laboratory Practice-compliant analytical facilities that will support bioanalytical research, product and regulatory package development; 4) provide Good Manufacturing Practice-compliant facilities for production of active pharmaceutical ingredient (API); 5) provide laboratories for preformulation, formulation and stability studies to characterize APIs; 6) provide laboratories for cellular and molecular mechanism of action and toxicity studies; and 7) provide laboratories for expansion of discovery efforts with greater emphasis on microbial and marine natural products. The requested funding will support construction to include 55,127 gross SF (partial first floor, 7,117; second floor 24,005; third floor, 24,005). Four laboratories of about 860 SF will be included in the first floor section, with eight laboratories each on the second and third floors; laboratory and building/mechanical support areas and office/cubicle/conference spaces are also included on each floor. Total net laboratory, office and support spaces to be constructed with this requested funding on the three floors will be 23,011 SF of new laboratory space, 9,773 SF of new office space, and 15,460 SF in support areas.