College of Medicine Phoenix Campus Vivarium Phase I Construction

描述（由申请人提供）：亚利桑那大学医学院-凤凰城与亚利桑那州立大学（COM-P）合作，于2006年在凤凰城生物医学校区招募了第一批新教师，目前在亚利桑那生物医学合作1 （ABC 1）中有22名教师和研究实验室。这些教师目前在凤凰城市区的各种aaalac批准的动物实验设施中进行动物研究。本建议的具体目标是支持在校园内建设一个12,100平方英尺的动物馆，以满足现有和未来的科学需求。这是目前计划在凤凰生物医学园区建设的一个更大的动物园内项目的第一阶段，同时还将建设健康科学教育大楼和ABC 2研究大楼。comp第一期动物饲养中心将包括动物饲养室，共可容纳4,158个鼠笼和1,200个鼠笼供啮齿动物居住。将为转基因小鼠品种的繁殖、大鼠和小鼠的专门行为分析、小鼠的动物生物安全2级（ABSL2）程序、大鼠和小鼠的检疫以及从实验室返回室内的啮齿动物的隔离提供房间。专门的套件包括行为分析，ABSL2密封和净化，以及小动物成像和辐照。此外，将专用区域清洁脏笼，储存食物和床上用品；动物收到;安乐死和兽医程序；用于生理测量、遥测、注射、血液和组织采集以及其他体内手术的外科设施和手术室。动物园内的啮齿动物将被安置在innovvive (R)单独通风的一次性（可回收）笼子系统中。此外，还提供带卫生间和淋浴的更衣室、工作人员室和办公室。要求的固定主要设备包括：两个2级B2型全耗尽生物安全柜，7个2级A2型生物安全柜，一个高压灭菌器，检查灯和一个反渗透Hydropak水袋生产系统。根据由参与的大学校长签署的气候变化倡议，该项目将以可持续发展的概念，包括回收、能源效率、减少用水和可持续的场地和开放空间规划，追求LEED银奖认证。COM-P一期Vivarium将提供急需的设施，以支持位于美国第五大城市的一所快速发展的新医学院现有的小灵通研究。该项目的及时授予和建设将创造或保留126个工作岗位，该设施的持续运营将创造或保留18个工作岗位。为了确保我们phs支持的研究工作所需的实验动物护理的最佳标准，最好也是唯一的方法是为凤凰城生物医学园区建设这个专用的实验动物饲养场。

DESCRIPTION (provided by applicant): The University of Arizona College of Medicine - Phoenix in Partnership with Arizona State University (COM-P) recruited its first new faculty to the Phoenix Biomedical Campus in 2006, and currently has 22 faculty with research laboratories in the Arizona Biomedical Collaborative 1 (ABC 1). Animal research by these faculty is currently conducted at various AAALAC-approved vivarium facilities throughout the Phoenix metropolitan area. The specific aim of the present proposal is to support construction of a 12,100 DGSF vivarium on campus to meet existing and future scientific needs. This represents Phase One of a larger vivarium project currently planned for the Phoenix Biomedical Campus along with construction of the Health Sciences Education Building and the ABC 2 research building. The COM-P Phase One Vivarium will include animal holding rooms with a total capacity of 4,158 mouse cages and 1,200 rat cages for rodent housing. Rooms will be provided for breeding of transgenic mice lines, specialized behavioral assays of rats and mice, animal biosafety level 2 (ABSL2) procedures in mice, quarantine of rats and mice, and segregation of rodents returning to the vivarium from laboratories. Specialized suites are included for behavioral analyses, ABSL2 containment and decontamination, and small animal imaging and irradiation. In addition, areas will be dedicated to clean and dirty cage, food and bedding storage; animal receiving; euthanasia and veterinary procedures; surgical facilities, and procedure rooms for physiological measurement, telemetry, injections, blood and tissue collection, and other in vivo procedures. The vivarium will house rodents in Innovive(R) individually ventilated, disposable (recyclable) caging systems. In addition, locker rooms with restrooms and showers, a staff room and office are provided. Fixed, major equipment requested includes: two Class 2, Type B2 fully exhausted biosafety cabinets, seven Class 2, Type A2 biosafety cabinets, an autoclave, examination lamps, and a reverse osmosis Hydropak water pouch production system. In accordance with the Initiative on Climate Change, signed by the participating University Presidents, this project will pursue LEED Silver certification with sustainability concepts, including recycling, energy efficiency, reduced water use and sustainable site and open space plans. The COM-P Phase One Vivarium will provide much needed facilities in support of existing PHS research at a new and rapidly growing medical college located in the fifth largest U.S. city. Timely award and construction of the project will create or retain 126 jobs, with ongoing operations of the facility creating or retaining 18 jobs. The best and only way to assure optimal standards of experimental animal care required for our PHS-supported research efforts is to construct this dedicated laboratory animal vivarium serving the Phoenix Biomedical Campus.