MSKCC Vivarium

描述(由申请人提供)：纪念斯隆-凯特琳癌症中心(MSKCC)正在为一项1974万美元的项目寻求1500万美元的联邦支持，该项目旨在扩大和装备现有的最先进的隔膜。由于经济状况疲软，MSKCC被迫停止了一座实验室研究大楼的二期建设，因此亟需的动物设施扩建工程未能完成。这一决定显然对确保中心的财务稳定是必要的，但却给MSKCC留下了足够的隔间空间。这个项目对该中心不断发展的研究事业至关重要，原因有很多。首先，动物模型的开发、表征和使用，特别是小鼠模型，对我们旨在了解和控制癌症的研究工作至关重要。其次，在过去的十年里，MSKCC研究人员对小鼠的利用急剧增长，这是由于新的教师招聘和强大的技术的发展，这些技术可以操纵小鼠基因组来改变癌基因和肿瘤抑制因子的表达。MSKCC现在已经到了正在进行的研究将受到可用动物空间的限制的地步。最后，MSKCC正在对其实验室研究计划进行重大扩展。这一扩展的主要目标是通过招募研究人员，包括对癌症转译研究感兴趣的内科科学家，来加强基础科学和临床科学之间的联系。由于这些研究人员显然将广泛使用动物模型，MSKCC的持续教师招聘严重依赖于额外动物空间的发展。该项目需要通过装修地窖和毗邻建筑的相关间隙/机械空间来扩大现有的间隔层。高效率(72%净额/毛数)的扩建将提供额外的31个小动物拘留室和13个动物程序实验室。扩建工程完成后，将额外提供23,450个独立通风的鼠笼，可容纳约100,000只老鼠。还需要资金购买高密度单独通风笼子系统(IVCS)；垂直换流站；生物安全柜；以及专为安全高效的啮齿动物二氧化碳安乐死而设计的专门IVCS。申请的资金将完全用于支持美国的就业。建筑和设备采购将创造大约20,000个工作日。工作人员满员时，每年需要7,250个工作日为间隔室配备工作人员。可持续的设计和施工方法是该项目的关键组成部分。MSKCC预计在建筑完工后获得LEED银牌认证。

DESCRIPTION (provided by applicant): The Memorial Sloan-Kettering Cancer Center (MSKCC) is seeking $15 M of federal support for a $19.74 M project to expand and equip an existing state-of-the-art barrier vivarium. As a result of weakening economic conditions, MSKCC was forced to cease construction on the second phase of a laboratory research building so a much-needed animal facility expansion was not completed. This decision, although clearly necessary to ensure the Center's financial stability, has left MSKCC with insufficient vivarium space. This project is vital to the center's growing research enterprise for a number of reasons. First, the development, characterization, and use of animal models, particularly mouse models, are critical to our research efforts aimed at understanding and controlling cancer. Second, the utilization of mice by MSKCC researchers has grown dramatically over the last decade, due to new faculty recruitments and the development of powerful technologies for manipulating the mouse genome to alter the expression of oncogenes and tumor suppressors. MSKCC has now reached the point where ongoing research will be limited by the available animal space. Finally, MSKCC is in the midst of a major expansion of its laboratory research programs. The principal goal of this expansion is to strengthen the interface between basic and clinical science by recruiting investigators, including physician-scientists, who are interested in translational cancer research. Since these investigators will clearly make extensive use of animal models, continued faculty recruitment at MSKCC is critically dependent upon the development of additional animal space. The project entails expanding an existing vivarium by fitting out the cellar and associated interstitial/mechanical space of a contiguous building. The highly efficient (72% net/gross) expansion will provide an additional 31 small animal holding rooms and 13 animal procedure laboratories. When complete, the expansion will provide an additional 23,450 individually ventilated mouse cages, with the capacity to house approximately 100,000 mice. Funding is also requested to purchase high density individually ventilated caging systems (IVCS); vertical flow changing stations; biological safety cabinets; and specialized IVCS designed for safe and efficient rodent CO2 euthanasia. The requested funds will be used entirely in support of American jobs. Approximately 20,000 worker days will be created by construction and equipment purchase. Seven thousand two hundred fifty worker days per year will be required to staff the vivarium when fully occupied. Sustainable design and construction methods are key components of the project. MSKCC anticipates obtaining LEED silver certification upon building completion.