Molecular Genetics of Tumor Viruses and Cells

产品说明： （申请人提供）拟参加培训的目的 该计划是准备高素质的男子和妇女的创造性职业， 基础癌症研究 与过去一样，该计划的主要重点是 基本细胞过程的分子遗传学研究培训 与理解癌症的病因学有关， 改进诊断和治疗方法。 该计划的教师是 约翰霍普金斯大学分子生物学和遗传学系的成员 霍普金斯大学医学院。 所代表的研究兴趣 其中包括：肿瘤病毒基因组的复制 和细胞，通过生长因子调节细胞增殖， 癌基因，哺乳动物细胞周期的控制， 正常和肿瘤中基因表达的调节 生长，反转录转座子的分子遗传学，细胞的机制， 信号转导及生长分化因子的作用 在发育和致癌过程中的作用。 学院十四名教师中的五名 培训计划的成员是一个国家癌症研究所支持的计划项目赠款，现在在 第二十五年，重点是基本的细胞机制， 控制细胞生长并维持基因组稳定性。 3个新增成员 接受ACS或其他私人癌症资助机构的直接支持 在过去的资助期内，其余的癌症相关工作 教师由其他机构（NIH和HHMI）支持。 这两个博士前（7）和博士后（4）学员支持下， 培训补助金。 博士前学员必须有一个强大的背景， o在定量科学方面的优秀本科成绩，以及 最好有包括遗传学在内的现代生物学背景。 他们必须 首先被生物化学跨部门研究生课程录取， 约翰霍普金斯大学生物学院的细胞和分子生物学 医学和必须圆满完成第一年的课程和实验室 这个节目的旋转。 在第一年结束时， 入读肿瘤病毒分子遗传学课程， 细胞以平均每年两个左右的速度， 七 其余的训练由实验室研究组成 旨在鼓励创造力和自力更生，要求选修课程 与基础癌症研究有关， 现代分子遗传学，并积极参加研究研讨会， 日记俱乐部 博士后必须完成博士学位的要求。或 M.D. 必须有杰出的成就和创新潜力 在基础或临床水平的癌症相关研究的职业生涯。 他们花 几乎所有的时间都在进行一个个人研究项目， 密切监督参与该计划的教员。 他们还 积极参加研究研讨会和期刊俱乐部， 整个项目人员，并酌情参加与以下相关的正式课程 大学内提供的癌症生物学。 该计划在招聘和培训方面拥有长期的成功记录 优秀的基础调查员 我们的大多数学生和 博士后学员将继续从事与癌症相关的基础研究， 高质量的学术机构或制药/生物技术 组织的

DESCRIPTION: (provided by Applicant) The purpose of the proposed training program is to prepare highly qualified men and women for creative careers in basic cancer research. As in the past, a primary emphasis of the program is research training in the molecular genetics of fundamental cellular processes relevant to understanding the etiology of cancer and ultimately developing improved methods for diagnosis and treatment. The faculty of the Program are members of the Department of Molecular Biology and Genetics at the Johns Hopkins University School of Medicine. The research interests represented among the faculty include: the replication of the genomes of tumor viruses and cells, the regulation of cellular proliferation by growth factors and oncogenes, the control of the mammalian cell cycle, the structure and function of chromosomes, the regulation of gene expression in normal and neoplastic growth, the molecular genetics of retrotransposons, the mechanisms of cellular signal transduction, and the functions of growth and differentiation factors in development and carcinogenesis. Five of the fourteen faculty of the Training Program are members of an NCI-supported program project grant, now in its twenty-fifth year, that is focused on basic cellular mechanisms that control cell growth and maintain genomic stability. Three additional members received direct support from the ACS or other private cancer funding agencies during the past grant period, while the cancer-related work of the remaining faculty is supported by other agencies (NIH and HHMI). Both predoctoral (7) and postdoctoral (4) trainees are supported under this training grant. Predoctoral trainees must have a strong background and o u t standing undergraduate accomplishment in quantitative science, and preferably some background in modern biology including genetics. They must first be accepted into the interdepartmental Graduate Program in Biochemistry, Cellular and Molecular Biology at the Johns Hopkins University School of Medicine and must satisfactorily complete the first year course and laboratory rotations of that program. At the end of the first year students are selected for admission into the Program in Molecular Genetics of Tumor Viruses and Cells at an average rate of about two per year with a steady state number of seven. The remainder of their training consists of laboratory research designed to encourage creativity and self-reliance, required elective courses related to basic cancer research, practical instruction in the techniques of modern molecular genetics, and active participation in research seminars and journal clubs. Postdoctoral trainees must have completed the requirements for the Ph.D. or M.D. and must have outstanding accomplishment and potential for creative careers in cancer-related research at a basic or clinical level. They spend almost all of their time carrying out an individual research project under the close supervision of a faculty member participating in the program. They also participate actively in research seminars and journal clubs involving the entire program personnel and, as appropriate, take formal courses related to cancer biology offered within the University. The Program has a long record of success in recruiting and training outstanding basic investigators. The majority of our students and postdoctoral trainees go on to careers in basic research relevant to cancer at high quality academic institutions or pharmaceutical/biotechnology organizations.