Quillen College of Medicine Building 119 Renovation

简介（申请人提供）：东田纳西州立大学詹姆斯·h·奎伦医学院成立于1974年。119号楼（105,000平方英尺）于1983年完工，最初是为研究和教学而建造的。今天，这座建筑用于研究，并容纳了2个基础科学部门和5个临床部门的研究项目。这些部门积极参与nih资助的若干领域的研究，包括神经科学、传染病和心血管疾病。119号楼还设有为健康科学校园服务的动物设施。该提案的总体目标是纠正119号楼的基础设施缺陷和主要固定设备故障，以满足nih资助的研究活动的现有需求，并通过提高现有科学家的生产力和招聘新研究人员来促进医学院的研究扩展。该拨款的具体目的是：(1)更换老化和故障的机械系统，(2)升级现有但不完善的电气系统，(3)翻新目前只有稀疏橱柜或架子的28个实验室，(4)升级不完善，故障或失效的固定设备，以及(5)翻新需要特定环境控制的研究实验室空间，例如显微镜，组织培养和动物设施。这里提出的改造广泛地贯穿于119号大楼，反映了对老化的研究基础设施进行升级的广泛而迫切的需求。拟议的改造将大大改善工作环境，提高能源效率，提高安全性，提供更合适的工作空间，从而直接促进当前和未来的研究。改进后的实验室条件将为扩展多个医学院院系的研究项目提供条件。福利将扩大到在119动物设施中饲养动物的其他健康科学研究人员（例如药学院）。

DESCRIPTION (provided by applicant): The James H. Quillen College of Medicine at East Tennessee State University was founded in 1974. Building 119 (105,000 sq ft) was completed in 1983 and was originally constructed for research and teaching. Today, this building is used for research and houses the research programs of 2 basic science and 5 clinical departments. These departments are actively engaged in NIH-funded research in several areas, including neuroscience, infectious disease, and cardiovascular disease. Building 119 also houses the animal facility that serves the Health Sciences campus. The overall goal of this proposal is to correct infrastructure deficiencies and major fixed equipment failures in Building 119 to meet the existing needs of NIH-funded research activities and to facilitate expansion of research at the College of Medicine through enhanced productivity of existing scientists and recruitment of new researchers. The specific aims of the grant are to (1) replace aged and failing mechanical systems, (2) to upgrade an existing but inadequate electrical system, (3) to renovate 28 laboratories that currently have only sparse cabinetry or shelving, (4) to upgrade inadequate, failing or failed fixed equipment, and (5) to renovate laboratory space for research that requires specific environmental controls, such as for microscopy, tissue culture, and the animal facility. The renovations proposed herein are widespread throughout Building 119, reflecting a broad and urgent need for upgrading an aged research infrastructure. The proposed renovations will greatly improve the work environment, improve energy efficiency, improve safety, provide more suitable workspaces, and thereby directly facilitate current and future research. The improved laboratory conditions will provide for expansion of research programs across several medical school departments. Benefit will be extended to other Health Science researchers (e.g. College of Pharmacy) that house animals in the 119 animal facility.