Construction Grant 8th Floor BRB

描述（由申请人提供）：在国家研究资源中心，美国国立卫生研究院，卫生与公众服务部的协助下，以及根据美国复苏法案有限竞争授予的资金：校外研究设施改善计划（C 06），马里兰州巴尔的摩医学院的大学提出改造20,000总平方英尺的实验室，办公室，和会议研究空间，位于弗兰克·C。Bressler研究大楼（BRB）为Marlene和Stewart Greenebaum癌症中心（UMCCC）。目前，BRB八楼的设施和设备已经严重过时，无法支持尖端的癌症研究。来自实验治疗学、激素反应性癌症以及分子和结构生物学（MSB）项目的UMGCC研究人员目前占据BRB的9楼和10楼。拟议改造的目标是巩固MSB计划中的基础研究人员的重点互动组，他们在细胞应激反应，结构生物学和基于结构的药物设计领域共享重叠的研究兴趣。 研究空间的共同定位将促进巩固来自MSB计划的主要合作研究人员在最先进的研究空间，从而促进该组之间以及与BRB 9楼和10楼的其他UMCCC研究人员之间的现有和新的互动。这些调查人员的接近也将加强与UMCCC共享服务的互动和利用，包括拟议的高通量筛选实验室。因此，我们设想新装修的空间的可用性将大大提高UMCCC的能力，以解决未满足的国家需要的新的和毒性较小的癌症患者通过促进多学科的转化癌症研究。UMB SOM预计该项目将通过在设计和施工中采用可持续方法来认证为利兹银项目。此外，在该项目的过程中，将创造大约120个新的美国就业机会，并将保持8至12个就业机会，否则将被淘汰。在等待批准和交付材料之前，该项目最早可于2009年12月开始，并于2011年8月完成。

DESCRIPTION (provided by applicant): With the assistance of the National Center of Research Resources, National Institutes of Health, Department of Health and Human Services and funds awarded under the American Recovery Act Limited Competition: Extramural Research Facilities Improvement Program (C06), the University of Maryland Baltimore School of Medicine proposes to renovate 20,000 gross square feet of lab, office, and conference research space on the eighth floor of the Frank C. Bressler Research Building (BRB) for the Marlene and Stewart Greenebaum Cancer Center (UMGCC). At the present time, the facilities and equipment on the eighth floor of BRB are significantly outdated and unable to support cutting-edge cancer research. UMGCC investigators from the Experimental Therapeutics, Hormone Responsive Cancers, and Molecular and Structural Biology (MSB) Programs currently occupy the 9th and 10th floors of BRB. The goal of the proposed renovation is to consolidate a focused interactive group of basic investigators in the MSB Program who share overlapping research interests in the area of cellular stress responses, structural biology, and structure-based drug design. The co-location of research space will promote consolidate key collaborating investigators from the MSB Program in state-of-the art research space, thereby promoting existing and new interactions among this group and with other UMGCC investigators on the 9th and 10th floors of BRB. The proximity of these investigators will also enhance interactions with and utilization of UMGCC Shared Services, including the proposed High-Throughput Screening Lab. Thus, we envision the availability of newly renovated space will dramatically enhance UMGCC's abilities to address the unmet national need for novel and less toxic therapies for cancer patients by promoting multidisciplinary translational cancer research. The UMB SOM anticipates this project will be certified as a LEEDS silver project by incorporating sustainable methods in the design and construction of this renovation. Furthermore, approximately 120 new American jobs will be created over the course of this project and between 8 and 12 jobs will be maintained that otherwise will be eliminated. Pending approvals, and delivery of materials this project can begin as early as December 2009 and be completed by August 2011.