Mckinly Laboratory Animal Facility Renovation and Expan*

这项建议是改造和扩大实验动物护理设施在较低的一层 特拉华大学麦金利实验室(UD)，包括卫生设施、空气处理和 支持设施。长期目标是扩大UD的开发和利用能力 在国家重点地区推广人类疾病转基因小鼠模型，并支持 癌症、心血管和神经科学研究项目。具体目标是(1)提供一种状态 ART小鼠屏障单位支持转基因和免疫折衷的开发和使用 动物模型；(2)为转基因啮齿动物提供额外的动物容纳量；(3) 更换现有的已有30年历史的空调系统；(4)扩大卫生面积，引入 支持动物设施功能的隧道清洗机；以及(5)达到或超过以下设施标准 AAALAC国际认证。 受益者是UD七个不同基础科学系的教职员工，这七个系 进行由美国国立卫生研究院资助的尖端研究。这笔赠款将使我们有可能为 招募更多依赖动物模型的NIH资助的研究人员；取消限制 NIH资助的研究人员目前必须设计他们的实验和方法学 围绕有限的动物设施；加快初级调查人员的职业发展；并改进 为本科生、研究生和博士后研究员提供研究培训机会。

This proposal is to renovate and expand the laboratory animal care facility on the lower level of the McKinly Laboratory at the University of Delaware (UD), including upgrades in sanitation, air handling and support facilities. The long term objectives are to expand UD's capacity for development and utilization of transgenic mouse models of human disease in national priority areas and support the growth of cancer, cardiovascular, and neuroscience research programs. Specific aims are to (1) provide a state of the art mouse barrier unit to support the development and use of transgenic and immunocompromised animal models; (2) provide additional animal holding capacity for genetically modified rodents; (3) replace the existing 30 year old air handling system; (4) expand the sanitation area and introduce a tunnel washer to support animal facility functions; and (5) meet or exceed the facility standards for AAALAC International accreditation. The beneficiaries are UD faculty members in seven different basic science departments which are conducting cutting edge research funded by NIH institutes. The grant will make it possible to facilitate recruitment of additional NIH-funded investigators who rely on animal models; remove constraints from present NIH-funded investigators who currently must design their experiments and methodology around limited animal facilities; accelerate the career development of junior investigators; and improve research training opportunities for undergraduates, graduate students, and postdoctoral fellows.