FASEB SUMMER RESEARCH CONFERENCE: BIOACTIVE LYSOLIPIDS

描述（由申请人提供）： 该提案要求部分资助将于2005年6月11日至16日在科罗拉多斯诺马斯村度假村举行的2005年FASEB夏季研究会议“健康和疾病中的生物活性溶血脂”。我们正在寻求资金，专门用于支付被邀请在会议上进行研究报告的一些初级、少数民族、女性和海外研究人员的差旅费和注册费。本次会议提供了一个独特的论坛，介绍和讨论生物活性溶脂介质领域的最新研究进展。这将是关于这一主题的第三次半年期会议。第一次会议有100名科学家参加，第二次会议有150名科学家参加，我们预计参加我们即将举行的会议的申请将超过200名与会者的会议限制。在我们的会议中这种快速增长的兴趣水平的主要原因是，现在很清楚，这个家族的脂质，其中包括溶血磷脂酸（LPA），鞘氨醇1-磷酸（S1 P）和相关分子，在生理学和病理生理学中发挥关键作用，竞争对手，在某些情况下超过肽生长因子。形成我们会议焦点的生物活性脂质在神经和心血管疾病的病因学，诊断和管理，免疫素质，缺血再灌注损伤，电离辐射和癌症的保护方面具有既定的功能。靶向溶血脂质及其受体的新型治疗剂已证明在治疗这些疾病中的几种中有效。自1990年代中期以来，这一领域的出版物呈指数增长，今年发表了约500篇相关文章。NIH通过所有主要研究所（主要是NCI，NHLBI NIAID和NIGMS）管理的基金支持我们会议领域的约130个活跃的研究项目。我们会议的主要目标是汇集和促进研究人员之间的讨论，合作和试剂和想法的交流，这些研究人员在这个令人兴奋的，不断增长的，全球活跃的和医学相关的研究领域中具有共同的兴趣。

DESCRIPTION (provided by applicant): This proposal requests funds in partial support of the 2005 FASEB Summer Research Conference on "Bioactive Lysolipids in Health and Disease" to be held from June 11-16, 2005 at the Snowmass Village Resort, Colorado. We are seeking funds specifically to pay the travel and registration costs of a select groups of beginning, minority, female and overseas-based investigators who have been invited to make research presentations at the conference. This conference provides a unique forum for the presentation and discussion of recent research progress in the area of bioactive lysolipid mediators. This will be the third biannual conference on this topic. The first meeting was attended by -100 scientists, the second by -150 and we anticipate that applications to attend our upcoming meeting will exceed the conference limit of 200 participants. The primary reason for this rapidly increasing level of interest in our conference is that it is now clear that this family of lipids, which include lysophosphatidic acid (LPA), sphingosine 1-phosphate (S1P) and related molecules, play critical roles in physiology and pathophysiolgy that rival and in some cases exceed those of peptide growth factors. The bioactive lipids that form the focus of our conference have established functions in the etiology, diagnosis and management of neurological and cardiovascular diseases, immunologic diathesis, ischemia reperfusion injury, protection from ionizing radiation and cancer. Novel therapeutics targeting lysolipids and their receptors have demonstrated efficacy in the treatment of several of these diseases. Publications in this field have increased exponentially since the mid 1990s with approximately 500 relevant articles published in the present year. The NIH supports approximately 130 active research projects in the area of our conference through funds administered by all of the major institutes, primarily the NCI, NHLBI NIAID and NIGMS. The primary objective of our meeting is to bring together and faciliate discussion, collaboration and exchange of reagents and ideas between researchers with converging interests in this exciting, growing, globally active and medically relevant research field.