Chemistry of mutagenesis

描述（由申请人提供）：本提案是为将于2005年8月28日至9月1日在华盛顿举行的美国化学学会全国会议上提交的为期半天的突变化学研讨会提供财政支持的请求。 本次研讨会的主题将是DNA聚合酶催化的致癌物损伤DNA的复制导致突变的机制。 这个话题非常重要，因为它是诱变和最终癌症的最终原因。 最近，已经有大量的研究通过Y家族旁路聚合酶复制受损的DNA。 这项工作的大部分集中在聚合酶的结构，并评估每个聚合酶的底物。 由“特邀演讲者”领导的最近的工作是了解为什么某些核苷酸插入受损DNA的机制。 受邀的演讲者是化学家，他们使用系统的结构和生物化学特性来阐明反应概况。 每个演讲者都在其专业领域享有国际声誉。 研讨会的目标是将化学诱变领域的专家聚集在一起，以便他们能够向科学界提供有关这些酶的教育，希望吸引新的研究人员进入该领域。

DESCRIPTION (provided by applicant): This proposal is a request for financial support for a half-day symposium on The Chemistry of Mutagenesis to be presented at the American Chemical Society National Meeting, Washington DC Aug. 28-Sept 1, 2005. The topic of this symposium will be the mechanisms by which DNA polymerase-catalyzed replication of carcinogen-damaged DNA leads to mutations. This topic is extremely important because it is the ultimate cause of mutagenesis and ultimately cancer. Recently there has been a large amount of research into replication of damaged DNA by the Y-family bypass polymerases. Much of this work has focused on the structure of the polymerases and to evaluate the substrates of each polymerase. More recent work, lead by the "invited speakers", has been to understand the mechanism of why certain nucleotides are inserted opposite damaged DNA. The invited speakers are chemists who use the structural and biochemical properties of the systems to elucidate the reaction profile. Each of the speakers has an international reputation in their areas of expertise. The goal of the symposium is to bring together experts in the chemical mutagenesis field so that they will be able to educate the scientific community concerning these enzymes with the hope of attracting new investigators to the field.