2005 Epigenetics Gordon Research Conference

描述(由申请人提供)：表观遗传学的研究涉及到基因产生表型的极其复杂的机制。它涉及到几乎所有生物体发育的方方面面，并很好地提醒人们，毕竟，基因型如何产生表型的本质并不完全存在于DNA中。本申请请求支持将于2005年8月7日至12日在新罕布夏州霍尔德内斯学校举行的第六届戈登表观遗传学研究会议。受邀的演讲者是在原核生物、真菌、纤毛虫、植物、蠕虫、昆虫和哺乳动物方面工作的主要研究人员，他们的演讲将涵盖当今最吸引人和最活跃的研究领域，包括分子和细胞记忆、细胞去分化、DNA不对称、DNA甲基化、RNA干扰、亲本印记、X染色体失活、顺变、倍性、开关、环境压力、基因组防御系统、位置效应、组蛋白修饰、癌症的表观遗传学、哺乳动物克隆和干细胞开发。这些话题与人类健康直接相关，因为表观遗传程序的中断是癌症、印记基因疾病(如Prader-Willi和Angelman综合征)以及智力低下障碍(如Rett和ICF综合征)的基础。 2005年戈登表观遗传学研究会议将为致力于这一广泛机制和有机体的研究人员提供一个独特的环境，让他们齐聚一堂，交流结果和想法。由于报名人数有限，正式和非正式讨论的时间都很充裕，而且着眼于促进新研究人员的职业生涯，这次会议的跨学科环境将促进创新思维和新颖的合作，这对表观遗传学领域的研究人员的成功至关重要。

DESCRIPTION (provided by applicant): The study of epigenetics concerns the enormously complex mechanisms by which genotype gives rise to phenotype. It pertains to every aspect of development in virtually all organisms, and has been a good reminder that the essence of how genotype gives rise to phenotype does not, after all, reside completely in DNA. This application requests support for the 6th Gordon Research Conference on Epigenetics to be held at Holderness School, New Hampshire, August 7-12, 2005. Invited speakers are leading researchers working on prokaryotes, fungi, ciliates, plants, worms, insects, and mammals, and their presentations will cover some of the most fascinating and actively-studied areas of science today, including molecular and cellular memory, cellular de-differentiation, DNA asymmetry, DNA methylation, RNA interference, parental imprinting, X-chromosome inactivation, paramutation, ploidy, switching, environmental stress, genome defense systems, position effects, histone modifications, epigenetics of cancer, mammalian cloning, and stem cell development. These topics have direct relevance to human health, since disruptions in epigenetic programs underlie cancer, imprinted gene disorders such as Prader-Willi and Angelman syndromes, and mental retardation disorders such as Rett and ICF syndromes. The 2005 Gordon Research Conference on Epigenetics will provide a unique setting for researchers working on this broad spectrum of mechanisms and organisms to come together and exchange results and ideas. With a limited enrollment, ample time for both formal and informal discussions, and an eye toward promoting the careers of new investigators, the cross-disciplinary environment of this conference will foster the innovative thinking and novel collaborations that are critical for the success of researchers in the field of epigenetics.