Gordon Research Conference on Calcium Signaling

描述(申请人提供)：申请资金用于支付将于2005年7月24-29日在英国牛津举行的关于钙信号的戈登研究会议的部分费用。钙是一种普遍存在的细胞内信使；它是许多细胞过程的重要调节因子，包括受精、细胞死亡、感觉转导、肌肉收缩、运动、胞吐和液体分泌。钙信号缺陷是多种疾病的一个特征，包括许多(例如高血压和免疫缺陷)，这些都是巨大的社会经济负担。该会议每两年举行一次(与补充的FASEB会议交替举行)，在欧洲和美国之间轮流举行。它为在钙信号的许多方面具有不同兴趣的科学家提供了主要的论坛，以回顾这一活跃领域的令人兴奋的发展。该计划已被选定，以包括那些在该领域最活跃的人，而不复制最近的GRC或FASEB会议。会议规模较小(限于140人，而且总是超额认购)，而且强调互动讨论，因此辩论十分活跃。有8次会议，选出主席以促进积极讨论，以及一次全体会议。海报是一项关键功能(大多数与会者都出席了)；每天下午都会展示海报，每届会议主席将选择一张海报(总共8张)作为演讲。在整个项目中，目标是建立参与钙信号的蛋白质的结构和功能之间的连续性，以及这如何导致对疾病状态的理解。会议致力于钙信号的空间组织，细胞内和质膜钙通道的结构和功能，色氨酸蛋白在正常和疾病状态下的作用，钙在分泌和血管功能中的作用，以及解码钙信号的会议。这些主题对许多疾病状态具有根本的重要性、广泛的兴趣和直接的相关性，包括神经退行性疾病和心血管疾病、衰老、癌症、感觉障碍和免疫性疾病。

DESCRIPTION (provided by applicant): Funds are requested to partially cover the costs of the Gordon Research Conference on Calcium Signaling to be held in Oxford, England from 24-29 July 2005. Calcium is a ubiquitous intracellular messenger; it is an essential regulator of many cellular processes including fertilization, cell death, sensory transduction, muscle contraction, motility, exocytosis and fluid secretion. Defective calcium signaling is a feature of diverse diseases, including many (e.g. hypertension and immunodeficiencies) that are huge socioeconomic burdens. The conference takes place biennially (interleaved with the complementary FASEB meeting) and alternates between Europe and the USA. It provides the premier forum for scientists with diverse interests in the many facets of calcium signaling to review exciting developments in this active area. The program has been selected to include those most active in the field without replicating recent GRC or FASEB meetings. The small size of the meeting (limited to 140 and invariably over-subscribed) and emphasis on interactive discussion ensure lively debate. There are 8 sessions, with chairs selected to promote active discussion, and a plenary. Posters are a key feature (most attendees present); they are presented each afternoon and each session chair will select a poster (8 in total) for presentation as a talk. Throughout the program the aim is to establish the continuity between the structure and function of proteins involved in calcium signaling and how that leads to an understanding of disease states. Sessions are devoted to the spatial organization of calcium signaling, the structure and function of intracellular and plasma membrane calcium channels, the roles of TRP proteins in normal and disease states, the roles of calcium in secretion and vascular function, and a session on decoding calcium signals. These topics are of fundamental importance, widespread interest and immediate relevance to many disease states including neurodegenerative and cardiovascular diseases, aging, cancer, sensory disorders, and immunological diseases.