2005 CELL BIOLOGY OF METALS GORDON CONFERENCE

描述(由申请者提供)：2005年金属细胞生物学戈登会议的主要目标是为这一迅速发展的分支学科开创一个新的戈登会议。第一次会议将聚集从资深研究人员到研究生的科学家，介绍和讨论真核系统中铜、铁和锌离子的细胞生理学的最新进展。金属的细胞生物学所包含的问题是细胞如何实现金属离子的动态平衡，以及细胞如何在这些机制中特别地感知不同的金属离子？最终，这样的系统有助于将正确的金属定位到大约三分之一的蛋白质中，这些蛋白质需要金属辅因子来折叠或催化。会议将涉及中枢神经系统中的金属离子动态平衡，金属离子动态平衡的组织间调节，金属离子和金属离子络合物的运输，金属离子在细胞内的运输，金属离子信号和细胞中金属的全球分析。一个重要的目标是解决存在于不同金属离子的动态平衡机制中的相互联系。会议的目的是召集就上述专题进行研究的研究人员和受训人员，以促进交流、合作和分享方法论方面的进展。金属细胞生物学会议的新颖性在于对与金属离子相关的细胞生物学问题的独特关注，以及对生命所必需的多种金属离子的综合考虑。

DESCRIPTION (provided by applicant): The principal objective of the 2005 Cell Biology of Metals Gordon Conference is to inaugurate a new Gordon Conference on this rapidly expanding sub-discipline. The first meeting will bring together scientists, ranging from established investigators to graduate students, to present and discuss the most recent advances in cell physiology of copper, iron and zinc ions in eukaryotic systems. The questions encompassed by cell biology of metals are how do cells achieve metal ion homeostasis and how do cells specifically sense diverse metal ions in these mechanisms? Ultimately, such systems facilitate the correct metals locating to the approximately one-third of proteins that require metal-cofactors for folding or catalysis. Sessions will deal with metal ion homeostasis in the central nervous system, intertissue regulation of metal ion homeostasis, transport of metal ions and metal ion complexes, intracellular trafficking of metal ions, metal ion signaling and global analyses of metals in cells. An important goal is to address the interconnections that exist in homeostatic mechanisms of different metal ions. The meeting aims to draw together the investigators and trainees carrying out research on the mentioned topics in attempt to promote communication, collaborations and share advances in methodologies. The novelty of the Cell Biology of Metals conference lies in the unique focus on cell biological issues related to metal ions and the integrated consideration of multiple metal ions that are essential to life.