CONFERENCE/WORKSHOP ON EPR SPECTROSCOPY AND IMAGING

描述(申请人提供)：第十一届生物电子顺磁共振波谱、成像和自旋捕获国际会议(EPR-2005)将于2005年9月4日至9日在俄亥俄州哥伦布市举行。会议将集中讨论广泛的电子顺磁共振(EPR)方法，以研究与人类健康相关的生物过程。两年一度的EPR会议/研讨会已成为讨论电子和核磁共振(EPR、MRI和PEDRI)技术进展的主要平台。在过去的几十年里，自由基在许多疾病的发病机制中的作用得到了很好的认识，包括癌症、动脉粥样硬化、缺血再灌注损伤、中风、糖尿病血管疾病和各种炎症性疾病。这些自由基统称为“活性氧/氮物种(ROS/RNS)”，是在应激的生物环境中产生的，并通过一系列导致组织损伤的反应而传播。在这些自由基的检测、表征和定量方面已经取得了很大的进展。EPR光谱仍然是最受欢迎的技术，它能够在体外和体内直接检测和定量这些自由基。当结合成像的能力时，获得关于组织中自由基分布的空间分辨信息已经成为这项技术的独特特征。尽管EPR技术有许多潜力和优势，但在生物和医学自由基领域的研究人员中，EPR技术尚未完全被认识到。造成这种情况的主要原因是缺乏对这项技术及其独特能力的认识。为了向非EPR社区传播EPR成像技术的优点，我们将组织一个为期5天的研讨会/会议，重点介绍体内EPR波谱和成像技术的生物医学应用。参与者将包括来自世界各地的EPR科学家、初级教师、年轻研究人员、博士后候选人和博士后研究员。这次会议的亮点之一是包括、教育和鼓励妇女和少数族裔学生以及进入EPR领域的新人。这次会议汇集了应用研究方面的专家以及仪器、技术、软件和数据库的建造者和开发者。本次会议的专题讨论会旨在继续进行卓有成效的思想交流，这是推动该领域成功进展的巨大动力。EPR-2005将保持海报会议和全体会议的传统形式，强调在每个主要领域取得的重大进展。这里募集的资金需要为36名来自美国的年轻科学家(研究生、博士后研究科学家和年轻研究人员)提供部分旅行支持，他们是从那些贡献了研究论文的人中挑选出来的，另外20名参与者将被邀请进行口头陈述。与会者获得旅行支助的资格将根据由国际咨询委员会美国成员组成的委员会为本次会议制定的一套标准来决定。将特别重视少数群体和女科学家，鼓励她们积极参与。

DESCRIPTION (provided by applicant): The 11th International Conference on the Biological EPR Spectroscopy, Imaging, and Spin-Trapping (EPR-2005) will be held September 4-9, 2005 in Columbus, Ohio. The meeting will focus on a wide spectrum of electron paramagnetic resonance (EPR) methods to study the biological processes pertinent to human health. The biennial EPR Conference/Workshop has become the major platform to discuss advances in electron and nuclear magnetic resonance (EPR, MRI, and PEDRI) techniques. During the last couple of decades the role of free radicals has been well recognized in the pathogenesis of many diseases, including cancer, atherosclerosis, ischemia-reperfusion injury, stroke, diabetic vascular disease, and a variety of inflammatory diseases. The radicals, collectively termed as "reactive oxygen/nitrogen species (ROS/RNS)", are generated in the biological milieu under stress and propagated through a cascade of reactions leading to tissue damage. A great deal of progress has been made in the detection, characterization and quantification of these radicals. The EPR spectroscopy still remains the most sought after technique that enables direct detection and quantification of these radicals in vitro as well as in vivo. Obtaining spatially resolved information on the distribution of the radicals in the tissue, when combined with the power of imaging, has become a unique feature of this technique. In spite of many potentials and advantages, the EPR technique is not yet completely recognized among the investigators in the field of free radicals in biology and medicine. The prime reason for this is the lack of awareness of the technique and its unique capabilities. In order to disseminate the virtues of the EPR imaging technology among the non-EPR community, we are organizing a 5-day workshop/conference, which will highlight the biomedical applications of the in vivo EPR spectroscopy and imaging technology. Participants will include EPR scientists, junior faculty, young investigators, doctoral candidates and post-doctoral fellows from all over the world. One of the highlights of this conference is to include, educate, and encourage women and minority students as well as newcomers to the EPR field. The conference brings together the experts on application studies as well as the builders and developers of instrumentation, techniques, software, and databases. Symposia at this conference are designed for the continued fruitful cross-fertilization of ideas that has been a tremendous driving force behind the successful advances in this field. EPR- 2005 will maintain the traditional format of poster sessions and plenary lectures, which highlight major advances in each of the major areas. The funds solicited here are needed to provide partial travel support to 36 younger scientists from the U.S. (graduate students, post-doctoral research scientists, and young investigators) following selection among those who have contributed research papers, and further 20 of those participants will be invited for oral presentations. The eligibility of a participant to receive travel support will be decided according to a set of criteria set by a committee consisting of the U.S. members of the International Advisory Committee for this meeting. Particular emphasis will be given to the minority and women scientists, encouraging their active participation.