1st International Symposium on Wound Healing and Technology (WHAT I)

简介(由申请者提供)：首届创伤愈合与技术国际研讨会2006年8月28日至30日在华盛顿大学举行的首届创伤愈合与技术国际研讨会(What I)将汇聚来自学术界和工业界的科学家、内科医生和工程师，概述创伤愈合方面的广泛技术进步和仍然存在的障碍。我与其他伤口愈合会议的显著不同之处在于，这次研讨会将强调使用生物材料、控制释放、组织工程和其他工程方法进行伤口愈合的先进方法。会议将集中讨论参与实验室和临床研究的材料科学家、工程师、生物学家和医生之间的合作，以促进伤口愈合技术的发展。此外，翻译研究将通过一些公司演示和工业科学家的观众参与而成为关注的焦点。伤口愈合是一个重要的讨论领域，因为尽管进行了数十年的基础研究，但研究人员和科学家仍然缺乏对慢性伤口失败的明确的基础性了解。即使了解了伤口愈合的潜在机制，重大问题仍然存在，特别是患有慢性伤口和严重烧伤的患者。组织工程构建已经进入市场，但成本很高，收益有限。不幸的是，美容效果受损是常态。仍然存在的主要挑战是诱导组织再生和在全层创面形成柔韧、成熟的真皮，并控制感染。用于伤口护理和组织工程的材料的生物相容性改善现在是可能的。对这些新想法的交流和讨论是这次会议的核心。另一项强大的技术是药剂的控制释放。到目前为止，只有一种处方药被批准用于促进慢性伤口的愈合--尽管已经进行了15年以上的研发和对许多候选化合物的调查。人们普遍怀疑，未能在正确的时间提供有效剂量是伤口愈合药物的一个主要潜在缺陷。因此，我将把临床医生的思想领袖、基础学术科学家和行业领袖聚集在一起，分享大胆的想法并促进交叉合作。首届创伤修复与技术国际研讨会创伤愈合是一个关键的讨论领域，因为尽管我们进行了几十年的基础研究，但我们仍然缺乏对慢性创伤失败的明确的基础性了解。不仅为了提高我们的知识，而且为了开发面向市场的材料和技术，参与实验室和临床研究的材料科学家、工程师、生物学家和医生必须共同努力。对这些问题的沟通和讨论以及我们如何解决这些问题的新想法是本次会议的核心。

DESCRIPTION (provided by applicant): 1st International Symposium on Wound Healing And Technology The 1st International Symposium on Wound Healing And Technology (WHAT I), August 28-30, 2006, at the University of Washington will bring together scientists, physicians and engineers from academia and industry to overview a broad spectrum of technology advances in wound healing and the barriers that remain. WHAT I is significantly different from other wound-healing conferences in that this symposium will emphasize advanced approaches to wound healing using biomaterials, controlled release, tissue engineering, and other engineering methodologies. The conference will focus on the collaboration between materials scientists, engineers, biologists, and physicians involved in laboratory and clinical research to advance wound healing technology. Also, translational research will be spotlighted with a number of company presentations and audience participation by industrial scientists. Wound healing is a significant area for discussion because researchers and scientists still lack a clear fundamental understanding of chronic wound failures, despite decades of basic research. Even when underlying mechanisms to wound-healing are understood, significant problems persist, especially with patients suffering from chronic wounds and severe burns. Tissue-engineered constructs have entered the marketplace, but the costs are high, and the benefits limited. Compromised cosmetic outcomes are unfortunately the norm. Major challenges that remain are to induce tissue regeneration and the formation of pliable, mature dermis in full-thickness wounds and to control infection. Improved biocompatibility of materials used in wound care and tissue engineering is now possible. Communication and discussion of these new ideas is central to this meeting. Another powerful technology is the controlled-release of pharmaceutical agents. To date, only one prescription drug has been approved to induce healing of chronic wounds-despite more than 15 years of R&D and investigations of numerous candidate compounds. It is widely suspected that failure to deliver an effective dose at the correct time is a major underlying deficiency of wound-healing pharmaceuticals. Thus, WHAT I will bring clinician thought-leaders, basic academic scientists, and industrial leaders together to share bold ideas and foster cross-cutting collaboration. 1st International Symposium on Wound Healing And Technology Wound healing is a critical area for discussion because we still lack a clear fundamental understanding of chronic wound failures, despite decades of basic research. In order to advance not only our knowledge, but to develop materials and technology for the market, it is imperative that materials scientists, engineers, biologists, and physicians involved in laboratory and clinical research work together. Communication and discussion of these problems and new ideas for how we can address them are central to this meeting.