Training in Engineered Biomaterials

工程生物材料培训

• 批准号: 7277317
• 负责人: Buddy D Ratner
• 金额: $ 20.54万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7277317
• 关键词: Biocompatible Materials; Engineering; Training

DESCRIPTION (provided by applicant): This proposal seeks to support the training of 9-12 Ph.D. students in the interdisciplinary field of Engineered Biomaterials. The training opportunities in the program encompass aspects of the engineering disciplines (Chemical Engineering, Materials Science Engineering, Bioengineering and Electrical Engineering), and the biological and physical sciences (Chemistry, Biology, Molecular Biology). The program is designed to provide an interdisciplinary education for graduate students in Chemical Engineering, Chemistry, Bioengineering, Materials Science Engineering and Electrical Engineering by integrating materials science, surface engineering, molecular biology, nanotechnology, chemistry, chemical engineering and medicine. In this training, graduate students will complete a series of core courses in basic engineering, biology, mathematics, and chemistry in accordance with individual departmental guidelines. Trainees will also complete specific courses in biomaterials engineering including courses such as molecular and cellular bioengineering, molecular recognition and design, molecular materials, biomaterials, and cellular interactions with biomaterials. Students will conduct thesis research under the guidance of the training program faculty that emphasizes the application of engineering principals to the design and development of biomaterials that exploit specific biological recognition mechanisms. Trainees in the Engineered Biomaterials program will learn to control biological reactions at interfaces with precision, to elucidate the biochemical/biological pathways that turn on healing and reconstruction, and to evolve implementable strategies to modify the surfaces of biomaterials and medical devices so they are recognized by the body and turn on healing and defined bioreactions. In addition, students will be exposed to the broader issues in biomaterials engineering and related disciplines via participation in research seminars, journal clubs, and attendance at national scientific meetings. The trainee' s educational experience will be further enhanced by opportunities to obtain experience in teaching, opportunities for industrial intemships, and by student workshops and seminars on issues of interest such as career opportunities. Trainees will be selected from highly qualified graduate students in the departments of Chemical Engineering, Bioengineering, Electrical Engineering, Chemistry and Materials Science and Engineering following completion of the qualifying exam and will be based on academic record, faculty recommendation, and a description of proposed research. Trainees will participate in the training program for a period of 2 years.

描述（由申请人提供）：该提案旨在支持 9-12 名博士生的培训。工程生物材料跨学科领域的学生。该计划的培训机会涵盖工程学科（化学工程、材料科学工程、生物工程和电气工程）以及生物和物理科学（化学、生物学、分子生物学）的各个方面。该项目旨在通过整合材料科学、表面工程、分子生物学、纳米技术、化学、化学工程和医学，为化学工程、化学、生物工程、材料科学工程和电气工程的研究生提供跨学科教育。在本次培训中，研究生将按照院系指导方针完成基础工程、生物、数学、化学等一系列核心课程。学员还将完成生物材料工程的具体课程，包括分子和细胞生物工程、分子识别和设计、分子材料、生物材料以及细胞与生物材料的相互作用等课程。学生将在培训计划教师的指导下进行论文研究，强调将工程原理应用于利用特定生物识别机制的生物材料的设计和开发。工程生物材料项目的学员将学习精确控制界面上的生物反应，阐明启动愈合和重建的生化/生物途径，并制定可实施的策略来修改生物材料和医疗设备的表面，以便它们被身体识别并启动愈合和定义的生物反应。此外，学生将通过参加研究研讨会、期刊俱乐部和参加国家科学会议，接触到生物材料工程和相关学科的更广泛问题。受训者的教育经验将通过获得教学经验的机会、工业实习的机会以及有关职业机会等感兴趣问题的学生讲习班和研讨会得到进一步增强。学员将在完成资格考试后从化学工程、生物工程、电气工程、化学和材料科学与工程系的高素质研究生中选拔，并将根据学业成绩、教师推荐和拟议研究的描述进行选择。学员将参加为期2年的培训计划。

项目成果

A ligand-mediated nanovector for targeted gene delivery and transfection in cancer cells.

• DOI: 10.1016/j.biomaterials.2008.10.003
• 发表时间: 2009-02
• 期刊: BIOMATERIALS
• 影响因子: 14
• 作者: Veiseh, Omid;Kievit, Forrest M.;Gunn, Jonathan W.;Ratner, Buddy D.;Zhang, Miqin
• 通讯作者: Zhang, Miqin

Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging.

• DOI: 10.1016/j.addr.2009.11.002
• 发表时间: 2010-03-08
• 期刊: ADVANCED DRUG DELIVERY REVIEWS
• 影响因子: 16.1
• 作者: Veiseh, Omid;Gunn, Jonathan W.;Zhang, Miqin
• 通讯作者: Zhang, Miqin

Complement activation on poly(ethylene oxide)-like radiofrequency glow discharge-deposited surfaces.

• DOI: 10.1002/jbm.a.32954
• 发表时间: 2011-01
• 期刊: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
• 影响因子: 4.9
• 作者: Szott, Luisa Mayorga;Stein, M. Jeanette;Ratner, Buddy D.;Horbett, Thomas A.
• 通讯作者: Horbett, Thomas A.

Structure and reactivity of adsorbed fibronectin films on mica.

云母上吸附的纤连蛋白膜的结构和反应性。

• DOI: 10.1529/biophysj.107.109819
• 发表时间: 2007
• 期刊: Biophysical journal
• 影响因子: 3.4
• 作者: Hull,JamesR;Tamura,GlenS;Castner,DavidG
• 通讯作者: Castner,DavidG

Inhibition of tumor-cell invasion with chlorotoxin-bound superparamagnetic nanoparticles.

• DOI: 10.1002/smll.200800646
• 发表时间: 2009-02
• 期刊: SMALL
• 影响因子: 13.3
• 作者: Veiseh, Omid;Gunn, Jonathan W.;Kievit, Forrest M.;Sun, Conroy;Fang, Chen;Lee, Jerry S. H.;Zhang, Miqin
• 通讯作者: Zhang, Miqin