FASEB Conference on Calcium and Cell Function

描述（由申请人提供）：申请资金用于2006年FASEB钙和细胞功能会议的部分支持，该会议将在科罗拉多州斯诺马斯举行。钙是一种重要的第二信使，对神经和免疫系统的发育和功能、生育、神经递质释放、感觉转导和细胞迁移等过程至关重要。因此，钙信号的缺陷与一系列影响可兴奋细胞和不可兴奋细胞的疾病有关。该会议每两年举行一次，旨在为来自不同领域的领先科学家提供一个论坛，以介绍和讨论钙领域最新和最令人兴奋的发展。我们的目标是吸引许多没有参加过以前钙信号会议的科学家，尽管他们的工作与会议的主题相关。特别是，许多研究感觉转导、神经元发育、神经生理学和突触传递的科学家没有参加过去的会议，因为以前的重点是不可兴奋的细胞。我们期望，在可兴奋细胞和不可兴奋细胞中工作的参与者，加上非正式的环境和相对适度的会议规模（最多165名参与者），将在通常不参加相同会议的科学家之间产生热烈的讨论和新的互动。会议将包括九个会议，口头报告，一个主题演讲和四个海报会议，涵盖的主题将包括钙在调节基因转录，发育和疾病中的作用，神经元胞外分泌，感觉信号和细胞迁移，以及钙释放和流入的分子机制，钙信号特异性。这些主题具有根本的重要性，并且与理解许多疾病的基础相关，包括神经变性；神经和免疫系统的发育缺陷；交际、感觉和认知障碍；肾脏和心血管疾病；免疫缺陷和自身免疫；和癌症。

DESCRIPTION (provided by applicant): Funds are requested to cover partial support for the 2006 FASEB Conference on Calcium and Cell Function, to be held in Snowmass, Colorado. Calcium is a critical second messenger, which is essential for processes ranging from nervous and immune system development and function to fertility, neurotransmitter release, sensory transduction and cell migration. Accordingly, defects in calcium signaling are associated with a host of diseases affecting excitable and non-excitable cells. The goal of this conference, which is held every two years, is to provide a forum for leading scientists from a diversity of fields to present and discuss the latest and most exciting developments in the calcium field. We have aimed to attract many scientists who have not participated in previous conferences on calcium signaling, despite the relevance of their work to the topic of the meeting. In particular, many scientists who work on sensory transduction, neuronal development, neurophysiology and synaptic transmission have not attended past meetings due to a former emphasis on non-excitable cells. We expect the mix of participants working with both excitable and non-excitable cells, combined with the informal setting and relatively modest size of the meeting (maximum of 165 participants), will generate lively discussions and new interactions among scientists who do not ordinarily attend the same conferences. The meeting will include nine sessions with oral presentations, one keynote address, and four poster session covering topics that will include the roles of calcium in regulating gene transcription, development and disease, neuronal exocytosis, sensory signaling, and cell migration, as well as molecular mechanisms of calcium release and influx, and calcium signaling specificity. These topics are of fundamental importance and are relevant to understanding the bases of numerous diseases, including neurodegeneration; developmental defects in the nervous and immune systems; communicative, sensory and cognitive disorders; kidney and cardiovascular disease; immunodeficiencies and autoimmunity; and cancer.