Lymphocyte Activation and Signaling

免疫系统的细胞装备有一系列令人眼花缭乱的信号受体，需要它们整合大量关于环境的信息，才能做出适当的生物反应。在过去的几年里，人们已经了解了许多关于单个受体与其配体相互作用所启动的信号级联的生化性质。这一进展提出了一个令人兴奋的新挑战，即了解如何在整个细胞的背景下整合多种信号，以实现最终的细胞反应。我们建议将致力于免疫细胞信号传递前沿的杰出科学家聚集在一起，描述他们的新发现，并解决这些问题与人类疾病的关系。拟议的会议将提供一种观点，说明首次相遇是如何 免疫细胞信号受体及其配体最终导致生物反应，无论是激活、分化、运动还是细胞死亡，以及这些知识是如何转化为自身免疫、免疫缺陷、疫苗、肿瘤免疫、移植和传染病等重要临床问题的。这次会议的组织者设计了一个项目，将把主要研究人员、研究员和学生聚集在一起，他们正在探索如何将信号通路整合到免疫细胞内和免疫细胞之间，以产生适当的反应，以及如何操纵这些信号通路来改变免疫细胞的功能，以达到治疗目的。

The cells of the immune system are armed with a dizzying array of signaling receptors requiring them to integrate an enormous amount of information about their environment to mount the appropriate biologic response. Over the last several years much has been learned about the biochemical nature of the signaling cascades initiated by interactions of individual receptors with their ligands. This progress presents an exciting new challenge, namely, to understand how multiple signals are integrated in the context of the entire cell to bring about the ultimate cellular response. We propose to bring together distinguished scientists working at the cutting edge of immune cell signaling to describe their new findings and to address how these issues relate to human disease. The proposed meeting will provide a view of how the initial encounter of immune cell signaling receptor with their ligands ultimately leads to the biological response be it activation, differentiation, movement, or cell death and how this knowledge is being translated to important clinical problems in autoimmunity, immunodeficiency, vaccines, tumor immunity, transplantation and infectious diseases. The organizers of this conference have designed a program that will bring together principal investigators, fellows and students who are exploring how signaling pathways are integrated within and among immune cells to yield the appropriate response and how these signaling pathways may be manipulated to alter immune cell function for therapeutic purposes.