SIGNAL TRANSDUCTION IN THE IMMUNE SYSTEM-FASEB CONF.

该申请寻求FASEB夏季会议的部分资金，该会议将于2005年6月18日至23日在科罗拉多的斯诺马斯举行。会议的主要目标将是全面关注有关免疫细胞反应的信号机制的最新进展，包括健康和疾病。了解这些信号转导途径是阐明感染，过敏，移植和恶性肿瘤的反应的分子基础的核心。免疫细胞信号传导在大学、研究机构和生物技术中存在广泛的兴趣。然而，在免疫学会议上的信号转导通常是作为一个附属主题，很少有详细的报道。2000年，第一次FASEB会议“免疫系统中的信号转导”提供了深入关注免疫系统中信号转导的细节。这次会议的成功使一些调查人员相信定期会议的价值。在此基础上，2003年夏季再次举行了会议，我们现在正计划在2005年夏季举行一次会议。2005年会议将涵盖一系列主题，重点是将不同的信号机制整合到免疫生物学的各个组成部分中。将有三个主要目标： 1)对控制各种免疫功能的信号蛋白的现状提供一个关键和深入的概述。我们的会议将涵盖从深入分析特定信号分子和网络到将这些知识应用于免疫生物学的全方位主题。 2)使资深科学家和年轻的研究人员聚集在一个愉快的气氛中进行介绍和非正式讨论。希望这种环境将有助于通过与知名调查人员的互动，培养学生和年轻调查人员的调查技能和热情。 3)继续为有兴趣全面关注免疫系统信号事件的研究人员举办一年两次的论坛。

This application seeks partial funding for a FASEB Summer Conference on "Signal Transduction in the Immune System", to be held June 18-23, 2005 in Snowmass, Colorado. The major goal of the conference will be to provide a comprehensive focus on recent advances regarding the signaling mechanisms involved in the responses of immune cells, both in health and in disease. An understanding of these signal transduction pathways is central to elucidating the molecular basis of the responses to infections, allergies, transplantation and malignancies. Widespread interest of immune cell signaling exists in universities, research institutes and biotechnology. However, signal transduction at immunology meetings is generally covered as an adjunct subject, with little detailed coverage. In 2000, the first FASEB meeting on "Signal Transduction in the Immune System" provided an in-depth focus on the details of signal transduction in the immune system. The success of that meeting convinced a number of investigators of the value of a regular meeting. On this basis, the meeting was repeated in the summer of 2003, and we arc now planning a meeting for the summer of 2005. The 2005 meeting will cover a spectrum of topics, with an emphasis on integrating the different signaling mechanisms into the various components of immune biology. There will be three main objectives: 1) To provide a critical and intensive overview of the current status of signaling proteins that control various immune functions. Our meeting will cover a full range of topics from an in-depth analysis of specific signaling molecules and networks, to the application of this knowledge to immunobiology. 2) To bring together senior scientists and young investigators in a convivial atmosphere of presentations and informal discussions. It is hoped that this environment will help develop the investigative skills and enthusiasm of students and young investigators by interacting with established investigators. 3) To continue a biannual forum for investigators interested in a comprehensive focus on signaling events in the immune system.