SIGNAL TRANSDUCTION IN THE IMMUNE SYSTEM-FASEB CONF.

本申请为将于2005年6月18日至23日在科罗拉多州斯诺马斯举行的FASEB夏季会议“免疫系统中的信号转导”寻求部分资金。会议的主要目标将是全面关注免疫细胞在健康和疾病反应中涉及的信号机制的最新进展。对这些信号转导途径的了解对于阐明对感染、过敏、移植和恶性肿瘤的反应的分子基础至关重要。大学、研究机构和生物技术对免疫细胞信号转导有着广泛的兴趣。然而，免疫学会议上的信号转导通常被作为一个辅助主题涵盖，几乎没有详细的报道。2000年，关于“免疫系统中的信号转导”的第一次FASEB会议深入讨论了免疫系统中信号转导的细节。那次会议的成功使一些调查人员相信了定期会议的价值。在此基础上，该会议于2003年夏季再次举行，我们现在计划在2005年夏季举行一次会议。2005年的会议将涵盖一系列主题，重点是将不同的信号机制整合到免疫生物学的各个组成部分中。将有三个主要目标： 1)对控制各种免疫功能的信号蛋白的现状进行关键和深入的概述。我们的会议将涵盖从对特定信号分子和网络的深入分析，到将这一知识应用于免疫生物学的所有主题。 2)将资深科学家和青年研究人员聚集在一起，在欢快的气氛中介绍情况和进行非正式讨论。希望这种环境将有助于发展学生和年轻调查人员的调查技能和热情，通过与老牌调查人员进行互动。 3)继续为对全面关注免疫系统中的信号事件感兴趣的研究人员举办一年两次的论坛。

This application seeks partial funding for a FASEB Summer Conference on "Signal Transduction in the Immune System", to be held June 18-23, 2005 in Snowmass, Colorado. The major goal of the conference will be to provide a comprehensive focus on recent advances regarding the signaling mechanisms involved in the responses of immune cells, both in health and in disease. An understanding of these signal transduction pathways is central to elucidating the molecular basis of the responses to infections, allergies, transplantation and malignancies. Widespread interest of immune cell signaling exists in universities, research institutes and biotechnology. However, signal transduction at immunology meetings is generally covered as an adjunct subject, with little detailed coverage. In 2000, the first FASEB meeting on "Signal Transduction in the Immune System" provided an in-depth focus on the details of signal transduction in the immune system. The success of that meeting convinced a number of investigators of the value of a regular meeting. On this basis, the meeting was repeated in the summer of 2003, and we arc now planning a meeting for the summer of 2005. The 2005 meeting will cover a spectrum of topics, with an emphasis on integrating the different signaling mechanisms into the various components of immune biology. There will be three main objectives: 1) To provide a critical and intensive overview of the current status of signaling proteins that control various immune functions. Our meeting will cover a full range of topics from an in-depth analysis of specific signaling molecules and networks, to the application of this knowledge to immunobiology. 2) To bring together senior scientists and young investigators in a convivial atmosphere of presentations and informal discussions. It is hoped that this environment will help develop the investigative skills and enthusiasm of students and young investigators by interacting with established investigators. 3) To continue a biannual forum for investigators interested in a comprehensive focus on signaling events in the immune system.