SIGNAL TRANSDUCTION IN THE IMMUNE SYSTEM-FASEB CONF.

描述（由申请人提供）：本申请寻求FASEB关于“免疫系统中的信号转导”的夏季会议的部分资金，该会议将于2003年6月14日至19日在科罗拉多的斯诺马斯举行。会议的主要目标是全面关注免疫细胞信号机制知识的最新进展。对信号转导途径的理解对于理解参与对感染性疾病、过敏、移植和恶性肿瘤的应答的各种免疫功能的分子基础至关重要。免疫细胞信号传导在大学、研究机构和生物技术中存在广泛的兴趣。然而，在免疫学会议上的信号转导通常是作为一个附属主题，很少有详细的报道。2000年，第一次FASEB会议“免疫系统中的信号转导”提供了一个深入的重点在免疫系统中的信号转导的细节。这次会议的成功使一些调查人员相信定期会议的价值。2003年的会议将涵盖从蛋白质和脂质激酶、磷酸酶到衔接蛋白（SLP-76、LAT、ADAP、3BP-2等）的一系列主题，质膜生物学和效应酶在基础生物学和疾病设置。本次会议将有三个主要目标：（1）提供控制各种免疫功能的信号蛋白的当前状态的关键和深入的概述。我们的会议将涵盖从深入分析特定信号分子和网络到将这些知识应用于免疫生物学的全方位主题。(2)使资深科学家和年轻的研究人员聚集在一个愉快的气氛中进行介绍和非正式讨论。希望这种环境将有助于通过与知名调查人员的互动，培养学生和年轻调查人员的调查技能和热情。(3)继续为有兴趣全面关注免疫系统信号事件的研究人员举办一年两次的论坛。

DESCRIPTION (provided by applicant): This application seeks partial funding for a FASEB Summer Conference on "Signal Transduction in the Immune System" to be held from June 14th-19th, 2003 in Snowmass, Colorado. The major goal of the conference is to provide a comprehensive focus on recent advances in the knowledge of signaling mechanisms of immune cells. An understanding of signal transduction pathways is central to an understanding of the molecular basis of various immune functions involved in the response to infectious disease, allergy, transplantation and malignancy. Widespread interest of immune cell signaling exists in universities, research institutes and biotechnology. However, signal transduction at immunology meetings is generally covered as an adjunct subject, with little detailed coverage. In 2000 the first FASEB meeting on "Signal Transduction in the Immune System" provided an in-depth focus on the details of signal transduction in the immune system. The success of that meeting convinced a number of investigators of the value of a regular meeting. The 2003 meeting will cover a spectrum of topics from protein and lipid kinases and phosphatases to adapter proteins (SLP-76, LAT, ADAP, 3BP-2 etc.), plasma membrane biology and effector enzymes in basic biology and disease settings. There will be three main objectives of this conference: (1) To provide a critical and intensive overview of the current status of signaling proteins that control various immune functions. Our meeting will cover a full-range of topics from an in depth analysis of specific signaling molecules and networks to the application of this knowledge to immunobiology. (2) To bring together senior scientists and young investigators in a convivial atmosphere of presentations and informal discussions. It is hoped that this environment will help develop the investigative skills and enthusiasm of students and young investigators by interacting with established investigators. (3) To continue a biannual forum for investigators interested in a comprehensive focus on signaling events in the immune system.