UECC ANIMAL FACILITY IMPROVEMENT GRANT

描述(由申请人提供)： 内布拉斯加州大学医学中心(UNMC)致力于追求动物研究的卓越标准。保持实验动物护理评估和认可协会(AAALAC)的认可是UNMC用来衡量这一目标完成情况的手段之一。比较医学(CM)于2001年8月1日重组至目前的配置，以巩固和集中UNMC校园和1个校外地点所有生物医学动物研究和教学的动物护理计划。CM支持动物护理项目，包括在奥马哈校区和1个校外地点的5个单独的动物设施和3个专用外科设施，并支持4所学院、1所学校、2个研究所、9个中心和研究生的教职员工的动物研究。在2001-02财政年度，CM为82多名首席调查人员提供了动物资源服务，涉及475多项动物方案。UNMC校区的助学金总额为5080万美元，其中包括NIH资助的2780万美元，比前五年增加了107%。UNMC的目标是在2005年左右获得每年1亿美元的研究资金。在2002-2003财政年度第二季度，UNMC获得了1000万美元的联邦研究补助金。UNMC大约99.9%的动物使用发生在主校园综合体中。大约16,952平方英尺英国《金融时报》目前正在对4230号楼的空间进行翻新，以提供一个全校范围的远程啮齿动物隔离和再衍生设施，该设施将利用柔性薄膜隔离器来饲养动物。一个新的43,821平方英尺。英国《金融时报》达勒姆研究中心(DRC)的动物设施正在校园西端建设中。我们在主校区的第二大隔膜是Eppley癌症中心(UECC)，建于1972年。2001年，负责研究的副校长办公室将UECC动物护理人员、设备和设施整合到CM之下。自那以后，在通风微型隔离器笼子和引擎罩方面进行了大量投资，以增加现有空间中的动物住所密度。UECC现有的两台高压灭菌器需要更换为更大容量的机器，以适应这种可供动物使用的“最先进”护理方式所发生的巨大变化。由于规模较小的高压灭菌器的限制，不可能提供额外的高密度住房。这些限制也削弱了屏障的外壳，如果不在不久的将来得到纠正，就会破坏我们为研究提供足够的无病毒抗体的啮齿动物的能力。因此，这一设施在军管中心校园内具有最高的翻修优先事项。该提案将提供与此次翻修有关的信息，该项目的完成将使UNMC能够为UECC的研究动物提供更多和更高质量的动物收容所。

DESCRIPTION (provided by applicant): The University of Nebraska Medical Center (UNMC) is committed to pursue a standard of excellence in animal research. Maintaining accreditation by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) is one of the means used by UNMC to measure accomplishment of this objective. Comparative Medicine (CM) was reorganized to its present configuration on August 1,2001 to consolidate and centralize the animal care program for all biomedical animal research and teaching on the UNMC campus and 1 off-campus location. CM supports animal care programs encompassing 5 separate animal facilities and 3 dedicated surgical facilities on the Omaha campus and 1 off-campus location, and supports animal research for the faculty of 4 colleges, 1 school, 2 institutes, 9 centers and Graduate Studies. In fiscal year 2001-02, CM provided animal resource services to over 82 principal investigators with over 475 animal protocols. Grant awards for the UNMC Campus totaled $50.8M including $27.8M in NIH funding, a 107% increase over the previous five years. UNMC's goal is to obtain an annual total of $100M in research funding around the year of 2005. UNMC received $10M in federal research grants during the second quarter of fiscal year 2002-2003. Approximately 99.9% percent of the animal use at UNMC occurs on the main campus complex. Approximately 16, 952 sq. ft. of space is currently under renovation in building 4230 to provide a campus-wide remote rodent quarantine and re-derivation facility that will utilize flexible film isolators for animal holding. A new 43, 821 sq. ft. animal facility, at Durham Research Center (DRC) is under construction on the West end of the campus. Our second largest vivarium on the main campus, the Eppley Cancer Center (UECC), was built in 1972. The Office of the Vice Chancellor for Research integrated the UECC animal care personnel, equipment, and facilities under CM in 2001. Significant investments in ventilated microisolator caging and hoods have since been made to increase animal housing density in existing space. UECC's two existing autoclaves need to be replaced with larger capacity machines to accommodate the tremendous changes that have occurred in this "state of the art" care available for animals. Additional high-density housing is not possible due to the limitations of the undersized autoclaves. These limitations have also weakened the barrier housing, which undermines our ability to provide enough viral antibody free rodents for research if not corrected in the near future. This facility, therefore, has the highest renovation priority on the UNMC campus. This proposal will provide information relative to this renovation and completion of the project will allow UNMC to provide improved quantity and quality animal housing for research animals at the UECC.