Core--Laboratory Services

在过去的五年里，加州大学伯克利分校儿童环境健康研究中心的实验室服务核心（实验室核心）为建立一个大型生物储存库提供了基础设施。The Core制定了样本收集、处理、加工和银行的标准操作程序。核心还制定和实施了质量管理计划，设计了定制数据库和全面的数据跟踪程序，并建立和验证了高通量方法来研究生物学终点。 在今后五年中，核心的主要目标将是继续并扩大其在支持中心研究项目方面的作用。核心工作人员将履行关键的实验室职能，包括收集更多的生物样本，并确保已储存的样本得到最佳储存。核心将监督新采集标本的采集、标记、处理和储存方案的制定和实施，包括活细胞冷冻保存和细胞因子分析的高级程序。核心将协调中心外地办事处、中心生物储存库和合作分析实验室（如疾病控制和预防中心（CDC））之间所有样本的运输。核心小组将继续确保遵守与样本采集、处理、运输、储存和数据管理的所有方面有关的质量保证和质量控制程序。 此外，中心生物储存库将成为新成立的加州大学公共卫生生物储存库学院的一个部门。通过汇集基础设施和资源，核心将加强和扩大其能力，为中心的研究项目提供最先进的实验室支持。

For the past five years, the Laboratory Service Core (Laboratory Core) of the Center for Children's Environmental Health Research at the University of California, Berkeley, has provided the infrastructure for the creation of a large biorepository. The Core has developed standard operating procedures for sample collection, handling, processing, and banking. The Core has also developed and implemented a Quality Management Plan, designed a custom database and comprehensive data tracking procedures, and established and validated high-throughput methods to study biological endpoints. Over the next five years, the primary goal of the core will be to continue and expand its role in support of the Center's research projects. Core staff will perform key laboratory functions, including collecting additional biological samples and assuring optimal storage of already banked samples. The Core will oversee the development and implementation of protocols for the collection, labeling, processing, and banking of newly collected specimens, including advanced procedures for viable cell cryopreservation and cytokine analysis. The Core will coordinate shipment of all samples between the Center field office, central biorepository and collaborating analytical laboratories, such as the Centers for Disease Control and Prevention (CDC). The Core will continue to ensure compliance with quality assurance and quality control procedures related to all aspects of sample collection, processing, shipping, storage, and data management. In addition, the Center Biorepository will become a division of the newly created University of California, School of Public Health Biorepository. By pooling infrastructure and resources, the Core will enhance and expand its ability to provide state of the art laboratory support to the Center's research projects.