Extinction and Active Coping Fear

描述（由申请人提供）：情感神经科学之一是详细的恐惧学习动物模型，已在人类研究中得到证实和扩展。 在这些依赖恐惧条件反射作为基本范式的动物模型中确定的神经系统与焦虑症和药物成瘾等心理障碍的发展有关。了解对这些疾病的发展至关重要的神经回路是将基础科学与治疗联系起来的第一步。下一步是了解这些习得的情绪反应如何被行动消除或改变。拟议研究的目标是探索人类和非人类物种条件性恐惧的消退和积极应对的神经机制，以及它们因焦虑症而改变的神经机制。 有三个具体目标： 目标1：开发物种间相似的灭绝和恐惧应对模式，以探索啮齿动物的特定神经机制，这些机制可以在人类中使用侵入性较小的技术进行评估。 目标二：确定通过消退的恐惧抑制的神经机制与积极应对/情绪调节策略的潜在机制之间的联系。 目标3：评估正常受试者和焦虑症患者在恐惧消退和积极应对的行为表达和神经机制方面的差异。

DESCRIPTION (provided by applicant): One of affective neuroscience is the of detailed animal models for fear learning that have been confirmed and extended in investigations with humans. The neural systems identified in these animal models, which have relied on fear conditioning as a basic paradigm, have been implicated in the development of psychological disorders, such as anxiety disorders and drug addiction. Understanding the neural circuits important for the development of these disorders is a first step in linking basic science to their treatment. The next step is to understand how these learned emotional responses can be extinguished or altered by action. The goal of the proposed research is to explore the neural mechanisms underlying the extinction and active coping of conditioned fear across human and non-human species and as they are altered with anxiety disorders. There are three specific aims: Aim 1: To develop paradigms of extinction and fear coping that are similar across species allowing for the exploration of specific neural mechanisms in rodents that can be assessed using less invasive techniques in humans. Aim 2: To determine the link between the neural mechanisms of fear inhibition through extinction with the mechanisms underlying active coping/emotion regulation strategies. Aim 3: To assess how the behavioral expression and neural mechanisms underlying fear extinction and active coping differs between normal subjects and patients suffering from anxiety disorders.