Hemorrhagic and Ischemic Stroke Among Blacks and Whites

描述（由申请人提供）：我们的主要目标是研究在一个拥有130万人口的大城市中中风的发病率、病因、治疗和结局的时间趋势，其中15%是黑人（2000年人口普查）。从2005年1月1日到2005年12月31日，我们将确定所有17家地区医院的每例住院卒中和TIA。我们还将通过在大辛辛那提/北方肯塔基州的5个县的143个门诊点筛查潜在病例来估计非住院卒中的数量。这些结果将与1993-94年和1999年期间采用相同方法确定的数据以及1988年期间所有脑内出血和蛛网膜下腔出血病例的数据进行比较。此外，我们将采访500名首次缺血性卒中患者和/或其家庭成员，以获得详细信息，包括功能结局和生活质量、当前健康状况、药物治疗、既往风险因素以及有关卒中体征和症状的知识，并将通过口腔细胞和/或血液收集遗传物质。最后，我们将在2006年重复1995年和2000年对我国人口中的2 000人进行随机数字拨号电话调查。估计的3200例卒中和800例TIA以及来自普通人群的2000例受调查者将用于检验一个主要假设和五个次要假设： 主要假设：卒中发病率的时间趋势因卒中亚型和人种而异。 次要假设：1。在2000年至2005年期间，了解中风警告信号或风险因素的人口比例将有所提高。 2. 1999年至2005年，接受溶栓治疗的急性缺血性中风患者比例将增加。 3.与白人相比，黑人卒中后经年龄调整的功能结局和健康相关生活质量明显较差。 4.与无卒中的匹配人群对照相比，缺血性卒中患者更有可能在编码磷酸二酯酶4D的基因内共享遗传变异和单倍型。 5.接受调查的人谁接受中风教育与快速记忆法将更有可能知道中风的警告信号后30天比那些谁接受标准的当前教育信息使用的大脑攻击联盟。

DESCRIPTION (provided by applicant): Our primary goal is to study temporal trends in the incidence rate, causes, treatment and outcome of stroke in a biracial metropolitan population of 1.3 million of whom 15 percent are black (2000 Census). For 1/1/2005 to 12/31/2005, we will identify every hospitalized stroke and TIA at all 17 regional hospitals. We will also estimate the number of non-hospitalized strokes by screening for potential cases at 143 outpatient sites in five counties in Greater Cincinnati/Northern Kentucky. These results will be compared with data identified by the same methodology during 1993-94 and 1999 and for all cases of intracerebral hemorrhage and subarachnoid hemorrhage during 1988. In addition, we will interview 500 first-ever ischemic stroke patients, and/or their family members, to obtain detailed information including functional outcome and quality of life, current health status, medications, prior risk factors, and knowledge about stroke signs and symptoms, and will collect genetic material via buccal cells and/or blood. Finally, we will replicate the 1995 and 2000 random digit-dialing telephone surveys of 2000 persons from our population during the year 2006. The estimated 3200 strokes and 800 TIAs as well as the 2000 surveyed persons from the general population will be used to test one primary hypothesis and five secondary hypotheses: Primary Hypothesis: Temporal trends in the incidence rate of stroke will vary by stroke sub-type and race. Secondary Hypotheses: 1. The proportion of the population that knows warning signs or risk factors for stroke will improve between 2000 and 2005. 2. The proportion of patients with acute ischemic stroke treated with thrombolytic therapy will increase between 1999 and 2005. 3. The age-adjusted functional outcome and health-related quality of life after stroke will be significantly worse for blacks as compared to whites. 4. Individuals with an ischemic stroke are more likely to share genetic variants and haplotypes within the gene encoding phosphodiasterase 4D as compared to matched population controls free of stroke. 5. Surveyed people who receive stroke education with the FAST mnemonic will be more likely to know stroke warning signs after thirty days than those who receive the standard current educational message used by the Brain Attack Coalition.