Experimental Analysis of Advanced Radiotherapy Dosimetry

描述（由申请人提供）：本项目的总体目标是了解非平凡系统误差在基于多叶准直器（MLC）的兆伏（MV）光子束调强放射治疗（IMRI-）输送和剂量计算的总体准确性中的作用。根据我们的初步数据，在调强放射治疗的交付和计划计算的非平凡的系统误差存在显着的频率，并有可能阴谋是临床意义。提出了一个完整的静态和动态MLC的调强放射治疗交付的实验表征。该实验表征包括使用新型辐射变色膜剂量成像系统对IMRT产生的剂量分布进行精确的同时测量，以及使用高速闪烁相机系统对所提供的场形状和注量进行精确的同时测量。从这项工作的结果将提供一个排名的重要性，不同来源的错误的发展战略，以尽量减少调强放射治疗的交付错误。来自该表征的数据将允许通过将这些测量参数的反馈结合到治疗计划算法中来补偿机械未对准和剂量输送误差。从这个Vantage出发，将评估IMRT剂量计算算法的准确性。这项工作的结果将提供一个范例，关闭临床治疗计划系统和MLC调强放射治疗输送系统之间的循环。

DESCRIPTION (provided by applicant): The overall aim of this project is to understand the role of nontrivial systematic errors in the overall accuracy of multileaf collimator (MLC) -based megavoltage (MV) photon-beam intensity modulated radiation therapy (IMRI-) delivery and dose calculation. According to our preliminary data, nontrivial systematic errors in IMRT delivery and plan calculation exist with significant frequency and have the potential to conspire to be clinically significant. A complete experimental characterization of static and dynamic MLC-based IMRT delivery is proposed. This experimental characterization includes the accurate simultaneous measurement of the dose distributions produced by IMRT using a novel radiochromic film dose-imaging system, and the delivered field shapes and fluences using a high-speed scintillation camera system. Results from this work will provide a ranking of the importance of the different sources of error for the development of strategies to minimize IMRT delivery errors. The data from this characterization will allow mechanical misalignment and dose delivery errors to be compensated for by incorporating the feedback of these measured parameters into a treatment-planning algorithm. From this vantage, the accuracy of the IMRT dose calculational algorithms will be assessed. Results from this work will provide a paradigm for closing the loop between the clinical treatment planning system and the MLC IMRT delivery system.