CORE--IMAGE ACQUISTION & ANALYSIS

描述（由申请人提供）：支持要求继续我们的NEI视力中心补助金在俄克拉荷马州健康科学中心（OUHSC）的大学。提出了四个模块：图像采集和分析，动物资源，生物信息学/蛋白质组学和分子生物学。这些模块为20名NIH资助的研究人员提供了基本服务，其中14人获得了NEI资格赠款。图像和动物模块位于Dean A. McGee Eye Institute（DMEI）位于经过翻新的设施中，其中包括2，000平方英尺的核心模块和12，000平方英尺的研究实验室。后两个位于生物医学科学大楼（BMSB），位于细胞生物学和生物化学与分子生物学系新装修的空间。所有模块和研究实验室都在三个街区内。自上次提交以来，9名NEI资助的研究人员已被招募到眼科和细胞生物学部门。核心支持的可用性是我们快速增长的主要贡献者。 这四个核心模块将通过核心人员提供稳定，集中的服务来提高OUHSC视觉研究活动的生产力。这些模块将通过提供允许多学科方法的资源来促进和加强资助项目;促进试点研究的启动;促进研究人员之间的合作研究项目;帮助OUHSC招募其他视力研究人员;为校园研究人员提供机会，与视力核心中心研究人员合作启动视力研究项目;并为研究生提供资源 和视觉研究实验室的博士后研究员。 从教务长，DMEI，眼科和细胞生物学系的机构支持将提供实验室空间;实验室空间的翻新资金;核心模块的部分支持，包括新仪器和核心人员工资的匹配资金;教师工资的部分支持;和工资和启动资金招聘2名新教师在未来4年。这种基础广泛的机构支持将确保每个核心模块的人员配备和供应，以完全满足OUHSC视觉研究人员的需求。

DESCRIPTION (provided by applicant): Support is requested for continuation of our NEI Vision Center Grant at the University of Oklahoma Health Sciences Center (OUHSC). Four Modules are proposed: Image Acquisition and Analysis, Animal Resources, Bioinformatics/Proteomics, and Molecular Biology. These modules provide essential services to 20 NIH-funded investigators with 14 NEI-eligible grants. The Image and Animal Modules are located in the Dean A. McGee Eye Institute (DMEI) in renovated facilities that include 2,000 square feet for the core modules and 12,000 square feet for research laboratories. The latter two are located in the Biomedical Sciences Building (BMSB) in newly renovated space in the Departments of Cell Biology and Biochemistry & Molecular Biology. All modules and research laboratories are within three blocks of each other. Since the last submission, 9 NEI-funded investigators have been recruited into the Departments of Ophthalmology and Cell Biology. The availability of core support is a major contributor to our rapid growth. These four core modules will increase productivity of the vision research activities at the OUHSC by providing stable, centralized services with core personnel. The modules will promote and enhance funded projects by providing resources that allow multidisciplinary approaches; facilitate the initiation of pilot studies; promote collaborative research projects between investigators; aid in the recruitment of other vision researchers to the OUHSC; provide opportunities for researchers on campus to initiate vision research projects, in collaboration with vision Core Center investigators; and provide resources for graduate students and postdoctoral fellows in vision research laboratories. Institutional support from the provost, DMEI, and the Departments of Ophthalmology and Cell Biology will provide laboratory space; funds for renovation of laboratory space; partial support for core modules, including matching funds for new instruments and core personnel salaries; partial support for faculty salaries; and salaries and start-up funds for the recruitment of 2 new faculty members over the next 4 years. This broad-based institutional support will ensure that each Core Module is staffed and supplied to completely serve the needs of vision researchers at the OUHSC.