Agents of International Health & Bioterrorism Concern

描述(由申请者提供)：阿拉巴马大学伯明翰分校提议进行一项博士后和博士后综合培训基金，重点是生物防御剂，包括新出现的和国际上感兴趣的关键生物。我们机构在微生物学、传染病流行病学、临床研究和产品开发方面的翻译工作方面的优势产生了这一领域的大量研究。因此，我们认为，现在是提供大规模培训拨款的最佳时机，以激发我们在后9/11、后炭疽时代所面临的大量工作所需的新专业知识。PI、执行委员会和核心导师在培训和相关研究方面都非常合格；我们是经验丰富的导师，将学员与资助和可资助的研究联系起来。我们的计划包括对少数族裔学员，特别是非裔美国人的特别招聘工作。对于类似的培训资助，我们提供经过良好审查的课程或模块，涉及研究伦理、资助撰写、手稿准备和IRB问题。我们的具体目标是：1.提供博士前培训，以获得流行病学、环境健康工程、环境健康科学或国际健康方面的研究学位，促进从事翻译研究的研究职业。2.通过研究方法、公共卫生、生物防御/新出现的传染病以及生物技术和疫苗开发方面的跨学科培训，使博士后学员能够在国际卫生/生物防务领域开始独立的研究生涯。研究和培训的重点是(1)临床和分子流行病学；(2)应用微生物学；和/或(3)生物防御/传染病快速反应、预防和控制的操作研究。我们是在对NRSA目前由NIAID支持的培训拨款进行全面审查后选择这些主题的，注意到它们非常以基础科学为导向，很少支持被现任公共卫生服务领导层如此明确地强调为最高优先事项的翻译研究。我们的实习生将考虑到这些应用目标，他们的研究将集中在这一翻译研究领域。

DESCRIPTION (provided by applicant): The University of Alabama at Birmingham proposes to conduct a combined pre-doctoral and post-doctoral training grant that focuses on agents of biodefense interest, including key organisms of emerging and international interest. The strengths of our institution in microbiology, infectious disease epidemiology, clinical research, and translational work towards product development have generated considerable research in this arena. Thus, we believe the timing is perfect for a major training grant to stimulate new expertise needed for the mountain of work that faces us in the post 9/11, post-anthrax era. The PI, Executive Committee, and core mentors are all highly qualified in both training and relevant research; we are experienced mentors, linking trainees to funded and fundable research. Our plans include special recruitment efforts for minority trainees, particularly African-Americans. With analogous training grants, we offer well vetted courses or modules in research ethics, grant-writing, manuscript preparation, and IRB issues. Our specific aims are to:1. Provide pre-doctoral training leading to a research degree in epidemiology, environmental health engineering, environmental health sciences, or international health, facilitating research careers in the conduct of translational research. 2. Enable post-doctoral trainees to initiate independent research careers in international health/biodefense through cross-discipline training in research methods, public health, biodefense/emerging infectious diseases, and biotechnology and vaccine development. The research and training foci are (1) clinical and molecular epidemiology; (2) applied microbiology; and/or (3) operations research into biodefense/infectious disease rapid response, prevention, and control. We have chosen these themes after a comprehensive review of NRSA training grants supported currently by the NIAID, noting that they are very basic-science oriented with very few in support of the translational research that is so explicitly highlighted as highest priority by current Public Health Service leadership. Our trainees will be recruited with these applied goals in mind and their research will be focused in this translational research area.