Training Program in Integrative Immunobiology

描述（由申请人提供）：免疫反应受环境因素（感染、光周期、有毒化学物质）、行为（吸烟、饮酒、营养）、激素/神经递质（性/应激类固醇和去甲肾上腺素）和各种其他影响。例如，2001年9月11日的恐怖袭击和随后的炭疽恐慌已经并将继续影响所有人的免疫功能。该日期对人类健康和疾病的长期影响尚不清楚，但预计会很严重。了解外部力量影响免疫功能的机制需要多学科的方法来研究决定对疾病的抵抗力和易感性的各种因素。俄亥俄州立大学的教师致力于研究影响免疫功能的环境和生理变量，尤其是压力、神经激素、性别、行为和感染的影响，这是国际公认的。13名教员将为该培训项目做出贡献，他们在博士前和博士后培训方面有着良好的记录，每个教员都为学员提供位于中心的最先进的实验室。采用多学科的方法，包括免疫学、神经科学、分子生物学、内分泌学、微生物发病机制、心理学、精神病学和药理学等方面的培训，学员将学习神经和内分泌系统影响免疫稳态的细胞、生化和分子机制。受训者将研究这些系统失调造成的健康后果，并亲自观察实验室研究与行为和健康结果的结合。候选人将根据过去的学习成绩、推荐信、学术工作（包括出版物和演讲）以及个人目标陈述进行评估。根据每位受训者所需的基础科学培训程度，博士前研究员的培训期为3年，博士后为2年。总之，我们将提供一个多学科的培训环境，不同于任何其他研究免疫系统在健康和疾病的基础科学和临床应用。

DESCRIPTION (provided by applicant): Immune responses are affected by environmental factors (infection, photoperiod, toxic chemicals), behavior (smoking, alcohol use, nutrition), hormones/neurotransmitters (sex/stress steroids and norepinephrine), and a variety of other influences. For example, the terrorist attacks of September 11, 2001, and the subsequent anthrax scare have affected, and will continue to affect, immune function in all individuals. The long-term consequences of that date on human health and disease are unknown, but are predicted to be significant. Understanding the mechanisms by which external forces influence immune function requires a multidisciplinary approach to studying the various factors that determine resistance and susceptibility to disease. The Ohio State University is internationally recognized for its faculty who are dedicated to studying the environmental and physiological variables that influence immune function, most notably the effects of stress, neurohormones, gender, behavior, and infection. The 13 faculty who will be contributing to this training program have a strong track record of predoctoral and postdoctoral training, and each provides trainees with centrally located state-of-the-art laboratories. Using a multidisiplinary approach that includes training in immunology, neuroscience, molecular biology, endocrinology, microbial pathogenesis, psychology, psychiatry, and pharmacology, trainees will study the cellular, biochemical, and molecular mechanisms by which immune homeostasis is influenced by the nervous and endocrine systems. Trainees will study the health consequences that result from dysregulation of these systems and observe firsthand, the integration of laboratory research with behavior and health outcomes. Candidates will be evaluated on the basis of past academic performance, letters of recommendation, scholarly work that includes publications and presentations, and a statement of personal goals. The training period will be three years for predoctoral and two years for postdoctoral fellows, depending on the extent of basic science training required for each trainee. In summary, we will provide a multidisciplinary training environment unlike any other for studying the basic science and clinical applications of the immune system in health and disease.