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Training Program in Integrative Immunobiology

综合免疫生物学培训计划

基本信息

批准号：
7274153
负责人：
VIRGINIA M SANDERS
金额：
$ 23.02万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-06-01 至 2009-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7274153
关键词：
Immunobiology Training Programs

项目摘要

DESCRIPTION (provided by applicant): Immune responses are affected by environmental factors (infection, photoperiod, toxic chemicals), behavior (smoking, alcohol use, nutrition), hormones/neurotransmitters (sex/stress steroids and norepinephrine), and a variety of other influences. For example, the terrorist attacks of September 11, 2001, and the subsequent anthrax scare have affected, and will continue to affect, immune function in all individuals. The long-term consequences of that date on human health and disease are unknown, but are predicted to be significant. Understanding the mechanisms by which external forces influence immune function requires a multidisciplinary approach to studying the various factors that determine resistance and susceptibility to disease. The Ohio State University is internationally recognized for its faculty who are dedicated to studying the environmental and physiological variables that influence immune function, most notably the effects of stress, neurohormones, gender, behavior, and infection. The 13 faculty who will be contributing to this training program have a strong track record of predoctoral and postdoctoral training, and each provides trainees with centrally located state-of-the-art laboratories. Using a multidisiplinary approach that includes training in immunology, neuroscience, molecular biology, endocrinology, microbial pathogenesis, psychology, psychiatry, and pharmacology, trainees will study the cellular, biochemical, and molecular mechanisms by which immune homeostasis is influenced by the nervous and endocrine systems. Trainees will study the health consequences that result from dysregulation of these systems and observe firsthand, the integration of laboratory research with behavior and health outcomes. Candidates will be evaluated on the basis of past academic performance, letters of recommendation, scholarly work that includes publications and presentations, and a statement of personal goals. The training period will be three years for predoctoral and two years for postdoctoral fellows, depending on the extent of basic science training required for each trainee. In summary, we will provide a multidisciplinary training environment unlike any other for studying the basic science and clinical applications of the immune system in health and disease.

描述（由申请人提供）：免疫反应受环境因素（感染、光周期、有毒化学品）、行为（吸烟、饮酒、营养）、激素/神经递质（性/应激类固醇和去甲肾上腺素）以及各种其他影响的影响。例如，2001年9月11日的恐怖袭击和随后的炭疽恐慌已经影响并将继续影响所有个体的免疫功能。该日期对人类健康和疾病的长期影响尚不清楚，但预计将是重大的。了解外力影响免疫功能的机制需要多学科的方法来研究决定对疾病的抵抗力和易感性的各种因素。俄亥俄州州立大学因其致力于研究影响免疫功能的环境和生理变量的教师而受到国际认可，最显着的是压力，神经激素，性别，行为和感染的影响。将为该培训计划做出贡献的13名教师在博士前和博士后培训方面有着良好的记录，每个教师都为学员提供位于中心的最先进的实验室。使用包括免疫学，神经科学，分子生物学，内分泌学，微生物发病机理，心理学，精神病学和药理学培训的多学科方法，学员将研究免疫稳态受神经和内分泌系统影响的细胞，生物化学和分子机制。受训者将研究这些系统失调导致的健康后果，并观察第一手资料，实验室研究与行为和健康结果的整合。候选人将根据过去的学习成绩，推荐信，学术工作，包括出版物和演讲，以及个人目标的声明进行评估。博士前研究员的培训期为三年，博士后研究员的培训期为两年，这取决于每个受训人员所需的基础科学培训的程度。总之，我们将提供一个不同于任何其他的多学科培训环境，用于研究免疫系统在健康和疾病中的基础科学和临床应用。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Short day lengths skew prenatal sex ratios toward males in Siberian hamsters.

短日照使西伯利亚仓鼠的产前性别比例向雄性倾斜。

DOI：
10.1086/648487
发表时间：
2010
期刊：
Physiological and biochemical zoology : PBZ
影响因子：
0
作者：
Navara,KristenJ;Workman,JoannaL;Oberdick,John;Nelson,RandyJ
通讯作者：
Nelson,RandyJ

Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge.

DOI：
10.1016/j.bbi.2010.05.011
发表时间：
2010-10
期刊：
BRAIN BEHAVIOR AND IMMUNITY
影响因子：
15.1
作者：
Wynne, Angela M.;Henry, Christopher J.;Huang, Yan;Cleland, Anthony;Godbout, Jonathan P.
通讯作者：
Godbout, Jonathan P.

Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1beta and anti-inflammatory IL-10 cytokines.