Integrative Pharmacological Sciences Training Program (IPSTP)

综合药理学科学培训计划（IPSTP）

• 批准号: 10268599
• 负责人: ANNE M. DORRANCE
• 金额: $ 37.39万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10268599
• 关键词: Pharmacology; Science; Training Programs

Project Summary / Abstract The Integrative Pharmacological Sciences Training Program (IPSTP) at Michigan State University is designed to support 2nd and 3rd year Ph.D. students pursuing dissertation research projects in the pharmacological sciences. Trainees and training faculty are drawn from 7 departmental Ph.D. programs (Biochemistry & Molecular Biology, Chemistry, Chemical Engineering and Materials Science, Microbiology & Molecular Genetics, Neuroscience, Pharmacology & Toxicology, and Physiology). The IPSTP will provide students with enhanced training in the fields of in vivo pharmacology, drug discovery, and big data. The research expertise of IPSTP training faculty is clustered into three overlapping themes: 1) the intersection of molecular mechanisms of disease with novel therapeutic design; 2) integration of endocrine and metabolic derangements with cancer and cardiovascular processes; and, 3) application of systems biology and bioinformatics to understand drug mechanisms and disease. Funds are requested to support 8 students (4 students entering the program per year). Dr. Neubig and Dr. Dorrance will serve as Co-Directors, Dr. Leinninger and Dr. Luyendyk will serve as Associate Directors. The Directors will be assisted by an Executive Committee composed of representatives from the programs and 2 student representatives. The program is also guided by an External Advisory Committee of experts from Pharmacology Ph.D. programs and the pharmaceutical industry. There are 8 core elements to the training plan: 1) a research project that leads to a Ph.D. dissertation and a contribution to knowledge in the pharmacological sciences; 2) three week-long intensive boot camps in drug discovery, in vivo pharmacology, and computational chemistry/big data; 3) a three-course curriculum in pharmacology and biostatistics, 4) training in scientific rigor and reproducibility 5) a Professional Development Forum; 6) participation in an annual program retreat; 7) a monthly journal club and chalk talk program, and 8) an individualized development plan program. Students will be expected to participate in the last four elements both during their direct T32 support period and for subsequent years until graduation. Trainees are also required to attend the Responsible Conduct of Research (RCR) workshop series provided by the Graduate School and program-specific RCR activities. Supplemental activities available to trainees include: 1) teaching opportunities; 2) participation in the NIH-funded MSU BEST program, and 3) field-trips to regional sites for non-academic careers. The IPSTP has developed a comprehensive plan to recruit highly qualified students including under-represented minority students. We have also developed comprehensive plans for program and student evaluation. Mentor training will also be required for all IPSTP program faculty and the quality of the mentoring received by the students will be assessed. The IPSTP will provide trainees with excellent research and professional training and will prepare them for research careers in academia, industry and government.

项目总结/摘要 密歇根州立大学的综合药理学培训计划（IPSTP）旨在 支持第二和第三年的博士学位。从事药理学博士论文研究项目的学生 以理工科为重学员和培训教师来自7个部门的博士。生物化学（Biochemistry & 分子生物学、化学、化学工程与材料科学、微生物学与分子遗传学、 神经科学、药理学和毒理学以及生理学）。IPSTP将为学生提供增强的 在体内药理学，药物发现和大数据领域的培训。IPSTP的研究专长 培训教师被分为三个重叠的主题：1）交叉的分子机制， 新的治疗设计的疾病; 2）内分泌和代谢紊乱与癌症的整合， 心血管过程; 3）应用系统生物学和生物信息学来理解药物 机制和疾病。资金要求支持8名学生（每年4名学生进入该计划）。 博士Neubig和Dorrance博士将担任联席董事，Leinninger博士和Luyendyk博士将担任助理 董事们。董事将由执行委员会协助，执行委员会由来自 项目和2名学生代表。该计划还由一个外部咨询委员会指导， 药理学博士专家方案和制药行业。有8个核心要素， 培养计划：1）一个研究项目，导致博士学位。论文和贡献的知识， 药理学科学; 2）为期三周的药物发现，体内药理学， 和计算化学/大数据; 3）药理学和生物统计学的三门课程，4）培训 5）专业发展论坛; 6）参加年度计划 务虚会; 7）每月杂志俱乐部和粉笔谈话计划，和8）个性化的发展计划方案。 学生将被要求在他们的直接T32支持期间参加最后四个元素， 直到毕业。学员还必须参加研究的负责任行为 (RCR)研究生院提供的系列研讨会和特定项目的RCR活动。补充 提供给学员的活动包括：1）教学机会; 2）参加NIH资助的MSU BEST 计划，和3）实地考察，以区域网站的非学术职业生涯。IPSTP开发了一个 全面计划招收高素质学生，包括代表性不足的少数民族学生。我们有 还为项目和学生评估制定了全面的计划。还需要导师培训 所有IPSTP计划的教师和学生收到的指导质量将进行评估。的 IPSTP将为学员提供出色的研究和专业培训，并为他们的研究做好准备 在学术界、工业界和政府中的职业生涯。