Molecular Basis of Microbial Pathogenesis

描述（由申请人提供）：传染病是世界范围内发病率、死亡率和经济生产力损失的主要原因。微生物耐药性、新出现的感染、使用微生物作为生物恐怖主义武器以及获得性免疫缺陷综合症（艾滋病）是目前尚未解决的传染病问题的例子。开发更好的方法来诊断、治疗和预防传染病和生物恐怖主义是国家的一个高度优先事项，实现这一目标将需要培训更多具有微生物发病机理专门知识的科学家。这是我们在科罗拉多大学健康科学中心的微生物发病机制的分子基础博士后培训计划的第一个竞争性更新申请。我们的培训教师目前由来自生物化学和分子遗传学，医学，微生物学，神经病学，儿科学和药理学系的18名高度互动的科学家组成。他们拥有杰出的NIH资助的微生物发病机制研究项目，博士后水平培训的成功记录，广泛的专业互动和优秀的研究设施。我们的计划为基础生物医学科学家和医生科学家提供微生物发病机制分子基础的跨学科，以实验室为基础的培训。我们的学员通过参加相关基础生物医学科学和科学伦理学的高级研究生课程，参加各种研讨会，期刊俱乐部和数据俱乐部，以及参加国家科学会议来补充他们的实验室研究，以展示他们的研究成果并与他们研究领域的专家互动。我们的计划的主要优势包括我们的培训教师的规模不断扩大，他们的跨学科专业知识的广度，合格申请人的不断增加和被录取的学员的高质量，培训活动的广泛范围，以及我们的学员和教师之间的广泛互动与博士，医学博士，和D.V.M.训练我们将积极从代表性不足的少数群体中招募合格的学员。我们以前的大多数博士后学员现在都是学术界，政府或生物技术/制药行业的成功研究科学家。

DESCRIPTION (provided by applicant): Infectious diseases are a major cause of morbidity, mortality and loss of economic productivity worldwide. Microbial drug resistance, emerging infections, use of microbes as bioterrorism weapons, and acquired immunodeficiency syndrome (AIDS) are examples of currently unsolved infectious disease problems. Developing improved methods to diagnose, treat and prevent infectious diseases and bioterrorism is a high national priority, and achieving that goal will require training additional scientists with expertise in microbial pathogenesis. This is the first competing renewal application for our postdoctoral training program on the Molecular Basis of Microbial Pathogenesis at the University of Colorado Health Sciences Center. Our training faculty currently consists of 18 highly interactive scientists from the Departments of Biochemistry and Molecular Genetics, Medicine, Microbiology, Neurology, Pediatrics and Pharmacology. They have outstanding NIH-funded research programs on microbial pathogenesis, documented success with postdoctoral-level training, extensive professional interactions, and excellent research facilities. Our program provides interdisciplinary, laboratory-based training on the molecular basis of microbial pathogenesis for basic biomedical scientists and physician-scientists. Our trainees supplement their laboratory research by taking advanced graduate-level courses in relevant basic biomedical sciences and scientific ethics, participating in a wide variety of seminars, journal clubs and data clubs, and attending national scientific meetings to present their research findings and interact with experts in their research areas. Major strengths of our program include the increasing size of our training faculty and the breadth of their interdisciplinary expertise, the increasing pool of eligible applicants and the high quality of the admitted trainees, the broad range of training activities, and the extensive interactions between our trainees and faculty members with Ph.D., M.D., and D.V.M. training. We will recruit actively for qualified trainees from under-represented minority groups. Most of our previous postdoctoral trainees are now successful research scientists in academia, government or the biotechnology/pharmaceutical industry.