CHANGES IN HEALTH: SOCIO-ECONOMIC STATUS AND PATHWAYS

描述（改编自研究者摘要）：白厅II研究 10 308名男女公务员，入职时年龄在35-55岁之间（1985-1988年）， 是为了研究特定的社会心理，生活方式， 生物化学和生理学因素作为可能的解释， 不等式这些暴露的真实年龄相关变化，或累积 纵向测量的暴露，假设预测SES的变化 健康随年龄的差异。在队列的10年随访中，NIA 支持资助数据收集，以重复健康成果计量 功能，认知功能，代谢综合征的组成部分， ApoE基因分型这个应用程序要求资金来分析数据 迄今为止收集的信息并为15年的具体内容做出贡献 队列的后续。这笔资金将使调查人员能够 积累更多的终点，并跟踪健康功能到老年， 他们的早期生活和中年生活暴露，从而使我们能够建立 疾病和健康不平等的心理社会和生物途径。 应用的目的是：（1）描述和解释变化模式 与SES相关的健康状况的年龄;（2）确定梯度是否 健康功能从退休前到退休的不同;（3）检查 社会经济地位与认知功能随年龄变化的关系;（4） 通过检查原因来研究连接SES的特定生物学途径 以及它们随年龄变化的后果。白厅二号研究是独一无二的 政府已作好准备，解答这些问题，并提供： SES的一个很好的衡量标准;纵向设计，参与者比较 在入口处的年轻允许检测变化的前因;重复的 暴露的措施;广泛的暴露数据; 检测与年龄相关的变化，及其与社会经济地位的相互作用; 成果，包括健康和认知功能， 代谢综合征、死亡率、非致命性诊断和病假。

DESCRIPTION (adapted from investigator's abstract): The Whitehall II study of 10,308 male and female civil servants aged 35-55 years at entry (1985-1988), was established to examine the role of specific psychosocial, lifestyle, biochemical and physiological factors as possible explanations of these inequalities. True age related changes in these exposures, or cumulative exposure measured longitudinally, are hypothesized to predict changes in SES differences in health with age. At the 10-year follow up of the cohort, NIA support funded collection of data to repeat outcome measures of health functioning, cognitive functioning, components of the metabolic syndrome and ApoE genotyping. This application requests funding to analyze the data collected to date and to contribute to specific elements of the 15-year follow-up of the cohort. This funding will enable the investigators to accumulate more endpoints and track health functioning into older age, relate them to early life and mid-life exposures, and thereby allow us to establish psychosocial and biological pathways of disease and health inequalities. The aims of the application are: (1) To describe and explain patterns of change with age in health status in relation to SES; (2) To determine if the gradient in health functioning differs from pre-retirement to retirement; (3) To examine the relationship between SES and change in cognitive function with age; (4) To investigate specific biological pathways linking SES by examining the causes and consequences of their change with age. The Whitehall II study is uniquely poised to address these questions, offering: civil service grade as an excellent measure of SES; longitudinal design with participants comparatively young at entry allowing the detection of antecedents of change; repeated measures of exposures; a wide range of exposure data; substantial power to detect age-related change, and its interaction with SES; wide range of health outcomes including health and cognitive functioning, components of the metabolic syndrome, mortality, non-fatal diagnoses and sickness absence.