Cancer Center Planning Grant (P20)

本申请代表一项计划补助金的提案，用于在俄克拉荷马州大学健康科学中心（OUHSC）建立一个NCI指定的癌症中心。拟议的计划是器官部位特定的，或者在基础科学和预防/控制科学的情况下，具有高度的翻译性质。每个项目的共同目标是降低癌症的发病率，促进癌症的早期诊断，通过改善多模式临床护理和跨学科基础科学来提高生存率，并促进对服务不足社区的推广。妇科和乳腺计划的成员具有重要的临床专业知识，积极的赠款资金和基础，临床和转化研究兴趣的多样性。在这两个项目中，基础科学家和临床研究者的整合是有意的。该模型在整个中心的扩展吸引了基础科学专业知识和细胞周期控制和致癌作用中描述的假设生成研究。社区癌症预防和控制研究的目标是外展，以社区为重点的医学和科学，以及为俄克拉荷马州其他服务不足的社区设计的倡议。这些领域的基础科学已经有了重要的临床专业知识和研究人员。发展和种子基金将用于鼓励方案增长和刺激新方案的发展。OUHSC将继续在过去五年中对该中心进行的重大投资，包括2000万美元的招聘，未来五年25，000平方英尺的门诊癌症课程的建设，该中心的主要目标是将NCI赞助的直接资金从4.4美元增加到4.5美元。每年的直接费用为800万美元。NCI癌症中心的进一步发展将确保对美国这一地区进行独特的癌症研究，并为目前没有其他NCI指定癌症中心的大量人口提供最先进的癌症护理。

This application represents a proposal for a Planning Grant to develop an NCI-designated Cancer Center at the University of Oklahoma Health Sciences Center (OUHSC). The proposed programs are either organ-site specific or in the case of both basic and prevention/control sciences, highly translational in nature. The common goals of each program are to decrease the incidence and promote early diagnosis of cancer, to improve survival via improving multi-modality clinical care and interdisciplinary basic science, and to facilitate outreach to underserved communities. Members of the Gynecology and Breast Programs have significant clinical expertise, active grant funding and a diversity of basic, clinical and translational research interests. In both of these programs, the integration of the basic scientists and clinical investigators has been intentional. Expansion of this model throughout the Center has drawn in basic science expertise and the kind of hypothesis-generating research described in Cell Cycle Control and Carcinogenesis. Community Cancer Prevention and Control Research targets outreach, community focused medicine and science, and initiatives designed to other underserved communities in Oklahoma. Significant clinical expertise and investigators in basic science in these areas already exist. Developmental and seed funds will be utilized to encourage programmatic growth and stimulate new program development. OUHSC will continue the significant investment that it has undertaken in the Center in the past five years including $20 million for recruitment, construction of a 25,000 square foot outpatient cancer course of the next five years a major goal of the Center will be to increase direct NCI sponsored funding from $4.4. million dollars to $8 million dollars in annual direct costs. Further growth of the OU Cancer Center will ensure unique cancer research to this region of the United States and accessibility for state of the art cancer care for a large population that currently has no alternative NCI-designated cancer center.