PCB Congener/Metabolite Patterns in Akwesasne Mohawks

描述（由申请人提供）：在与莫霍克民族在Akwesasne，大学在奥尔巴尼进行了广泛的调查多氯联苯（PCB）污染在Akwesasne，并收集了大量的接触，健康和莫霍克儿童和成人的临床数据。 该实验室研究的长期目标是确定Akwesasne Mohawks人和其他接触人群体内多氯联苯（PCB）负荷的个人决定因素，包括与受污染生物群消费有关的因素。 身体负荷是多氯联苯（PCB）对健康潜在损害的一个重要预测指标，其特征是组织中存在的单个PCB同系物的绝对和相对水平。 多氯联苯（PCB）体内负荷受多种毒性相关因素和毒代动力学因素的影响。 该更新申请将通过应用多变量探索性数据分析和其他统计技术，扩大目前关于Akwesasne Mohawk人群中多氯联苯（PCB）暴露特征的工作，目标是确定源，途径和毒代动力学特定的暴露指标。 五个主要贡献血清多氯联苯（PCB）配置文件先前确定在莫霍克成人的存在将与相关的人口，暴露和环境变量。 这项研究将扩大到包括对莫霍克儿童和青少年队列中确定的多氯联苯（PCB）概况进行比较分析。 为提供数据以评估当前的体内负荷、同系物特征随时间的变化以及个别同系物的消除动力学，将对100份成人的新血液标本进行分析。 最后，一个补充数据库的主要血清羟化多氯联苯（PCB）代谢物在成年莫霍克将建立比较统计分析。 这些拟议的研究预计将促进在Akwesasne进行的多氯联苯（PCB）接触和健康影响研究，并对了解这些化合物的潜在健康风险具有重要意义。

DESCRIPTION (provided by applicant): In partnership with the Mohawk Nation at Akwesasne, the University at Albany has conducted extensive investigation of polychlorinated biphenyl (PCB) contamination at Akwesasne and has collected a large amount of exposure, health, and clinical data for Mohawk children and adults. The long-term objective of research in this laboratory is to identify individual determinants of polychlorinated biphenyl (PCB) body burden, including those related to consumption of contaminated biota, in the Akwesasne Mohawks and in other exposed populations. Body burden, which is characterized by the absolute and relative levels of individual polychlorinated biphenyl (PCB) congeners present in tissue, is an important predictor of potential health impairment from polychlorinated biphenyls (PCBs). Multiple exposure-related and toxicokinetics-mediated factors can influence polychlorinated biphenyl (PCB) body burden. This renewal application will expand current work on characterizing polychlorinated biphenyl (PCB) exposure in the Akwesasne Mohawk population by application of multivariate exploratory data analysis and other statistical techniques, with the goal of identifying source-, route-, and toxicokinetics-specific exposure indicators. The presence of five major contributing serum polychlorinated biphenyl (PCB) profiles previously identified in Mohawk adults will be correlated with relevant demographic, exposure, and environmental variables. The study will be expanded to include comparative analyses of polychlorinated biphenyl (PCB) profiles determined in a cohort of Mohawk children and adolescents. To provide data to assess current body burden, time-dependent changes in congener profiles, and elimination kinetics of individual congeners, new blood specimens will be analyzed from 100 adults. Finally, a complementary database of major serum hydroxylated polychlorinated biphenyl (PCB) metabolites in adult Mohawks will be established for comparative statistical analysis. These proposed studies are expected to facilitate ongoing exposure and health effects studies of polychlorinated biphenyls (PCBs) at Akwesasne and are important for understanding the potential health risks from these compounds in general.