Molecular Biology and Gene Therapy in Burns and Trauma

描述(由申请者提供)：本培训计划的总体目标是为两名正在接受培训的外科住院医生或其他致力于创伤、损伤、烧伤或炎症研究的临床住院医生提供为期两年的重点研究经验。该研究计划将侧重于掌握分子生物学、功能基因组学和基因疗法，因为它适用于创伤、脓毒症和烧伤的炎症研究。该计划将利用医学院在不断扩大的基因治疗、功能基因组学和分子生物学领域的独特优势，以及国家公认的基础科学家和临床医生之间不断发展的合作，致力于培训未来的临床院士。基因治疗、功能基因组学和分子生物学的基础科学与炎症研究之间的接口将针对成人呼吸窘迫综合征(ARDS)、全身炎症反应综合征(SIRS)或脓毒症综合征、缺血/再灌注损伤、伤口愈合延迟和烧伤创面以及中枢神经系统损伤等问题。这些教师将来自佛罗里达大学医学院外科、产科和妇科、神经科学和分子遗传学以及微生物学系的基础科学家，他们将担任学员的研究导师。外科和麻醉科(重症监护医学)的临床导师将与学员和研究人员互动，以确保学员接触到 临床--炎症研究中的重要问题。 该计划的总体指导将由首席调查员和执行委员会负责。 该奖学金的候选人将在全国范围内和从佛罗里达大学医学院外科系普通外科住院医师计划中招募。成功的申请者将在执行委员会的协助下确定一名研究和临床导师，该导师将协助制定正式的培训计划，并定期审查受训人员的进度。培训计划的大部分将在经验丰富的研究导师的实验室进行，但受训人员也将被要求完成研究伦理和统计方法方面的基本课程工作，并将被鼓励获得分子生物学和基因疗法的补充教学培训。此外，受训人员还将参加基因治疗中心及其基础科学部门的研讨会，以及每周的实验室研究会议。他们还将参加临床研讨会，包括外科和重症监护医学大轮。预计成功的毕业生将拥有足够的研究技能，以竞争炎症研究的过渡资金。

DESCRIPTION (provided by applicant): The overall goal of this training program is to provide a focused two year research experience for two surgical residents-in-training or other clinical house officers expressing a commitment to a career in trauma, injury, burn or inflammation research. The research program will focus on mastery of molecular biology, functional genomics and gene therapy as it applies to inflammation research in trauma, sepsis and burns. This program will take advantage of the unique strengths of the College of Medicine in the expanding field of gene therapy, functional genomics and molecular biology, as well as the developing collaborations between nationally recognized basic scientists and clinicians dedicated to the training of future clinical academicians. The interface between the basic science of gene therapy, functional genomics and molecular biology, and inflammation research will be targeted to the problems of adult respiratory distress syndrome (ARDS), SIRS or sepsis syndromes, ischemia/reperfusion injury, delayed wound healing and the burn wound, and CNS injury. The faculty will be drawn from basic scientists in the Departments of Surgery, Obstetrics and Gynecology, Neuroscience and Molecular Genetics and Microbiology at the University of Florida College of Medicine, who will serve as research mentors to the trainees. Clinical mentors from the Departments of Surgery and Anesthesiology (Critical Care Medicine) will interact with the trainees and the research faculty to assure that the trainees are being exposed to clinically-important issues in inflammation research. Overall direction of the program will rest with the Principal Investigator and the Executive Committee. Candidates for the fellowship will be recruited nationally and from the University of Florida College of Medicine Department of Surgery General Surgery Residency Program. Successful applicants will with the assistance of the Executive Committee identify a research and clinical mentor who will assist in the formulation of a formal training program and periodic review of the trainee's progress. The bulk of the training program will be in the laboratory of an experienced research mentor, but trainees will also be required to fulfill basic course work in research ethics and statistical methods, and will be encouraged to obtain supplemental didactic training in molecular biology and gene therapy. Furthermore, trainees are expected to participate in seminars in the Gene Therapy Center, and in their basic science departments, as well as weekly laboratory research meetings. They will also be expected to attend clinical seminars, including Surgery and Critical Care Medicine Grand Rounds. It is anticipated that successful graduates will possess sufficient research skills to compete for transitional funding in inflammation research.