Integrated Training in Reproductive Sciences

描述(由申请者提供)：本培训计划的目标是培养生殖内分泌医生和其他科学家在基础科学或临床科室从事生殖生物学工作。在过去的20年里，该培训计划已经开始运作，在此期间，82名博士后实习生(53名医学博士，29名博士)27名研究生接受了培训。该计划是多方面的，基础广泛，整合了分子内分泌学、细胞生物学、细胞信号、遗传学和生理学。研究培训将由生殖科学中心(CRS)的15名成员提供，他们在医学院的基础科学和临床系都担任教职。直接负责研究培训的经验丰富的项目教员具有广泛的科学专长和兴趣。目前的研究项目涉及生殖生物学的重要问题，包括：类固醇激素受体的作用机制；类固醇和神经类固醇激素生物合成和作用的分子遗传学和调控；生殖道的发育；促性腺激素释放激素神经元搏动的机制；子宫内膜和胎盘功能的调节；男性和女性不孕的遗传学；胎儿肾上腺的生长、发育和分化；性别决定；正常和异常生殖功能的内分泌调节。学员在向CRS提出正式申请后由指导委员会挑选，对于博士前学生，则由指导委员会选择适当的研究生课程。研究生攻读生物医学博士学位或生物科学课程。博士后培训将提供给相关学科的博士候选人，也将提供给拥有医学博士学位和以前的专业培训的临床培训的科学家。除了规定的课程作业和实验室或临床研究外，受训人员还将参加一系列定期安排的课程、研讨会、期刊俱乐部、会议和关于负责任的研究行为的研讨会。学员学习设计和执行基础研究项目，分析数据，并为著名的同行评议期刊撰写手稿。学员还准备和提交校外资助申请，为他们的独立学术生涯做进一步的准备。该计划的优势包括：1)教员的不同技能和兴趣2)教员的互动性3)教员丰富的实验室资源4)加州大学旧金山分校生殖、内分泌学、细胞生物学、遗传学和相关领域的卓越研究环境。

DESCRIPTION (provided by applicant): The objective of this Training Program is to prepare reproductive endocrine physicians and other scientists for careers in reproductive biology in basic science or clinical departments. The training program has been operative for the past 20 years during which time 82 postdoctoral trainees (53 M.D., 29 Ph.D.) and 27 graduate students have received training. The program is multifaceted and broadly based, integrating molecular endocrinology, cell biology, cell signaling, genetics, and physiology. Research training will be provided by the 15 members of the Center for Reproductive Sciences (CRS) who hold faculty positions in the School of Medicine in both basic science and clinical departments. The experienced Program Faculty members who are directly responsible for the research training have a broad range of scientific expertise and interests. Current research programs address important issues in reproductive biology including: mechanism of steroid hormone receptor action; molecular genetics and regulation of steroid and neurosteroid hormone biosynthesis and action; development of the reproductive tract; mechanism of GnRH neuronal pulsatility; regulation of endometrial and placental function; genetics of male and female infertility; fetal adrenal growth, development and differentiation; sex determination; endocrine regulation of normal and abnormal reproductive function. Trainees are selected by a Steering Committee following formal application to the CRS and, in the case of predoctoral students, to an appropriate graduate program. Graduate students pursue a course of study leading to the Ph.D. degree in Biomedical Sciences or Program in Biological Sciences. Postdoctoral training will be offered to Ph.D. candidates in related disciplines, and also to clinically trained scientists with M.D. degrees and prior specialty training. In addition to prescribed course work and laboratory or clinical research, trainees will participate in a series of regularly scheduled courses, seminars, journal clubs, conferences, and seminars on the responsible conduct of research. Trainees learn to design and execute basic research projects, analyze data and write manuscripts for prominent peer-reviewed journals. Trainees also prepare and submit grant applications for extra-mural funding, preparing them further for independent academic careers. The strengths of the program include: 1) diverse skills and interests of the faculty 2) the interactiveness of the faculty 3) the substantial laboratory resources of the faculty 4) the outstanding environment for research in reproduction, endocrinology, cell biology, genetics and related areas at UCSF.