Northern California Cooperative Family Registry for Breast Cancer

描述(由申请人提供)：自1995年成立以来，乳腺癌家庭登记中心(Breast CFR)是一个由六个合作网站组成的国际联盟，已经登记了超过13,000个家庭，涉及广泛的乳腺癌风险。北加州乳腺癌家庭登记处(NC-FRBC)为这一资源做出了重大贡献，收集了关于家族史、流行病风险因素和饮食摄入量的高质量数据，以及2600多个家庭的生物检疫数据，其中包括1900个少数族裔家庭，占所有登记的少数族裔家庭的70%。NC-FRBC为Breast CFR带来了许多优势，例如经验丰富的领导和合作伙伴、基于人口的抽样、有针对性的少数族裔招募、新的分析方法和成功的数据利用。这笔为期5年的续期拨款的目标是：1)建立和维护一个以假设为导向的研究基础设施，以加快和实施乳腺癌遗传流行病学方面的合作、多学科和多机构研究；2)将现有基础设施重组为9个核心平台，并维持和进一步加强现有资源；以及3)额外招募830个以人口为基础的少数族裔家庭(470个西班牙裔，360个非裔美国人)。与每个平台相关的核心活动包括：a)对1995-2005年登记的先证者和亲属进行系统的跟踪，并继续对1995-2009年登记的所有先证者进行年度跟踪；b)扩大在特别感兴趣的家庭(即多个病例早发和BRCA1和SRC/42突变携带者)中的数据和生物样本收集；c)扩大关于先证者和受影响亲属的临床和预后数据收集；d)扩大肿瘤块收集以构建组织微阵列；e)加强现有的生物样本资源并建立一个重复资料库；f)扩大BRCA1和BRCA2突变检测；g)维持和加强本地信息学能力；H)为促进行为和心理社会研究提供资源；i)协调内部登记职能，并与乳房疾病预防控制中心和外部调查人员合作。这一增强和扩大的资源将促进广泛的研究，从确定与乳腺癌风险有关的遗传因素及其与环境和其他遗传修饰因素的相互作用，到针对乳腺癌的临床、行为和预防方面的转化性研究。

DESCRIPTION (provided by applicant): Since the establishment in 1995, the Breast Cancer Family Registry (Breast CFR), an international consortium of six collaborating sites, has enrolled over 13,000 families across a wide range of breast cancer risk. The Northern California Family Registry for Breast Cancer (NC-FRBC) has contributed significantly to the resource and collected high-quality data on family history, epidemiologic risk factors and dietary intake, as well as biospecimens for over 2,600 families, including 1,900 minority families, which account for 70 percent of all enrolled minority families. The NC-FRBC brings many strengths to the Breast CFR, such as experienced leadership and collaborative partners, population-based sampling, targeted recruitment of minorities, new analytic methods, and successful data utilization. The objectives of this 5-year renewal grant are to: 1) establish and maintain a hypothesis-driven research infrastructure to expedite and implement collaborative, multi-disciplinary and multi-institutional research in genetic epidemiology of breast cancer; 2) re-structure the current infrastructure into nine Core Platforms and maintain and further enhance the existing resources; and 3) recruit an additional 830 population-based minority families (470 Hispanics, 360 African Americans). Core activities associated with each Platform include: a) conduct a systematic follow-up of probands and relatives enrolled from 1995-2005, and continue annual follow-up of all probands enrolled from 1995-2009; b) expand data and biospecimen collection in families of special interest (i.e., multiple case early-onset and BRCA1 and SRC/42 mutation carriers); c) expand clinical and prognostic data collection on probands and affected relatives; d) expand tumor block collection to construct tissue microarrays, e) enhance existing biospecimen resources and establish a duplicate repository; f) expand BRCA1 and BRCA2 mutation testing; g) maintain and enhance local informatics capabilities; h) contribute to resources to facilitate behavioral and psychosocial research; and i) coordinate internal registry functions and collaborations with Breast CFR and external investigators. This enhanced and expanded resource will facilitate a broad spectrum of research, ranging from identification of genetic factors related to breast cancer risk and their interactions with environmental and other genetic modifiers, to translational studies addressing clinical, behavioral and preventive aspects of breast cancer.