Function of the Vitamin D Receptor in Hepatic Non-Parenchymal Cells

核受体是控制新陈代谢许多方面的传感器，包括对损伤的反应。我们的研究表明，维生素D受体（VDR）可能在肝脏如何对损伤做出反应以及肝脏是否会留下疤痕并发展为肝硬化方面发挥着至关重要的作用。我们的实验将确定是否如此，以及VDR在哪些细胞中起作用。这项工作将为今后改善或预防严重肝脏疾病的治疗提供基础。

Nuclear receptors are sensors that control many aspects of metabolism, including responses to injury. Our work and has suggested that the Vitamin D Receptor (VDR) may play a vital role in how the liver responds to damage and whether the liver will the scar and move on to cirrhosis. Our experiments will determine if this is so, and in which cells VDR has this role. This work will provide a basis for future treatments to improve or prevent severe liver diseases.