Synthesis and measurements with multimodal sensing arrays

我们之前已经证明，交叉反应传感阵列是研究复杂混合物的有力工具，包括血液、废水和威士忌等饮料。从交叉反应阵列产生有意义的结果的关键，也是我的小组关注的主要领域，是对目标和受体的超分子理解的传感器化学的开发和设计。(1)在成功开发了基于分子和纳米颗粒传感器元件的生物分子和饮料阵列之后，（2,3）我们现在将注意力转向更适合仪器设计和需求点应用的基于基板的传感器。(4)与生物医学工程学院（Clark）合作，我们将采用分子设计实现检测血清中的肝脏疾病和废水中的污染物的阵列，但通过光刻纳米结构上产生的表面等离子体共振（SPR）进行转导。将合成针对肝脏疾病的关键生物标志物或关键废水污染物（药品、农药、全氟化合物）的新型化学物质阵列，并将开发方法，以便使用液体处理工具和测量在传感器基板上沉积。这将为未来研究提供开创性的高通量多区域SPR工具奠定基础。

We have previously shown that cross-reactive sensing arrays are a potent tool in the study of complex mixtures, including blood, waste waters, and beverages such as whisky. Key to generating meaningful results from a cross reactive array, and a main area of focus in my group, is the development and design of sensor chemistry with a supramolecular understanding of the targets and receptors.(1) Having successfully developed arrays for biomolecules and beverages based on molecular and nanoparticulate sensor elements,(2,3) we now turn our attention to substrate-based sensors, more suited to instrumental design and point-of-need applications.(4) In collaboration with Biomedical Engineering (Clark) we will implement arrays with molecular designs for sensing liver disease in serum, and pollutants in waste waters, but transduced by surface-plasmon resonance (SPR) generated on lithographic nanostructures. Novel arrays of chemistries will be synthesised that target key biomarkers of liver disease, or key waste-water pollutants (pharmaceuticals, pesticides, perfluorinated compounds), and methodology development will be undertaken to enable deposition on sensor substrates, using liquid handling tools, and measurement. This will form the basis for a ground-breaking high-throughput multi-region SPR tool for future studies.