Realistic models of gastrointestinal bioelectromagnetism

描述(由申请人提供)： 随着简化论生物医学在分子水平上成功地阐明了更多的细节，数学建模框架将变得越来越重要，以应对这种数据爆炸，并将完整的整个器官功能与利用这种分子知识的潜在生物物理详细机制联系起来。这项拟议的研究有两个主要的长期目标。首先是开发一个可扩展的基于解剖学和生物物理学的建模框架，该框架可用于集成胃肠道(GI)系统的生理、解剖和医学知识。第二个目标是将这个综合建模框架集中在影响美国相当数量的人的两种主要胃肠道疾病上，即肠缺血和糖尿病胃轻瘫。先前的研究表明，使用多通道超导量子干涉装置(SQUID)磁力计记录胃肠道电活动的磁场提供了对胃肠道平滑肌生理状态的非侵入性、非接触性评估。我们将结合多通道鱿鱼和皮肤电极测量与基于解剖学的综合计算机模型来研究肠缺血和胃轻瘫对胃肠电活动的无创影响。我们假设，由此产生的解剖和生理生物物理特性的整合将作为更完整地了解胃肠道系统的基础，并将有助于检测和诊断，并最终有助于胃肠道疾病的治疗。这必然是一个合作项目，最初涉及四个小组(范德比尔特大学的Living State物理小组、范德比尔特大学的外科系、生理和细胞生物学系、内华达大学医学院和奥克兰大学的生物工程研究所)，并将基于生物物理的综合建模专业知识与胃肠道系统功能的生理、临床和研究专业知识相结合。

DESCRIPTION (provided by applicant): As reductionist biomedical science succeeds in elucidating ever more detail at the molecular level, a mathematical modeling framework will become increasingly important to cope with this explosion of data and to relate integrated whole organ function to underlying biophysically detailed mechanisms that exploit this molecular knowledge. The proposed research has two primary long term objectives. The first is to develop an extensible anatomically and biophysically based modeling framework that can be used to integrate the physiological, anatomical and medical knowledge of the gastrointestinal (GI) system. The second objective is to focus this integrative modeling framework on two major diseases of the GI tract which affect a significant number of people in the United States, namely intestinal ischemia and diabetic gastroparesis. Prior research has shown that recordings of the magnetic field from gastrointestinal electrical activity using multichannel Superconducting QUantum Interference Device (SQUID) magnetometers provides a noninvasive, noncontact assessment of the physiological state of the GI smooth muscle. We will combine multichannel SQUID and cutaneous electrode measurements with anatomically based integrative computer models to investigate the inter- and intra-subject effects of intestinal ischemia and gastroparesis on GI electrical activity noninvasively. We hypothesize that the resulting integration of anatomical and physiological biophysical properties will serve as a basis for a more complete understanding of the gastrointestinal system and will aid in the detection and diagnosis and ultimately, in the treatment of gastrointestinal disorders. This is necessarily a collaborative project that initially involves four groups (the Living State Physics Group at Vanderbilt University, The Department of Surgery at Vanderbilt University, the Department of Physiology and Cell Biology, University of Nevada School of Medicine and the Bioengineering Institute at The University of Auckland) and combines expertise in integrated biophysically based modeling with physiological, clinical and research expertise in the function of the gastrointestinal system.