Adjustable Helmet Array for Neonatal Magnetoencephalography

用于新生儿脑磁图的可调头盔阵列

• 批准号: 8791327
• 负责人: Vishal K Shah
• 金额: $ 73.21万
• 依托单位: QUSPIN
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-21 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8791327
• 关键词: Address; Adopted; Adult; Algorithms; Appearance; Area; Automobile Driving; Brain; Calibration; Complex; Computer software; Coupled; Custom; Data; Development; Devices; Diagnosis; Electronics; Elements; Evaluation Reports; Fiber; Financial compensation; Frequencies; Functional Imaging; Functional disorder; Goals; Head; Helmet; Human; Imaging Techniques; Infant; Investments; Lasers; Lead; Light; Magnetism; Magnetoencephalography; Mental Retardation; Metals; Modification; Mus; Neonatal; Neuraxis; Neurodevelopmental Disorder; Noise; Operating System; Output; Patients; Peripheral; Persons; Phase; Positioning Attribute; Price; Research Infrastructure; Research Personnel; Risk; Sales; Shapes; Side; Signal Transduction; Slide; Source; Surface; System; Technology; Temperature; Testing; Universities; Variant; Width; Wisconsin; atomic transition; base; biomagnetism; cost; data acquisition; human subject; magnetic field; neonate; neurodevelopment; outcome forecast; patient safety; postnatal; prototype; public health relevance; sensor; superconducting quantum interference device

DESCRIPTION (provided by applicant): The goal of this project is to develop a very low-cost, whole-head neonatal MEG system that can adapt to the shape and size of the head. Clinically, there is a longstanding need for a technology that can aid in the diagnosis and prognosis of babies with brain dysfunction due to intrauterine and postnatal central nervous system insults, which may result in mental retardation and neurodevelopmental disorders. The proposed system is completely non-invasive and is based on a recent breakthrough in atomic magnetometer technology that eliminates the majority of the costs and complexity associated with the use of superconducting sensors in traditional MEG systems. In the Phase I project, we identified and addressed all major technical risk elements, and successfully demonstrated the viability of our approach. In Phase II we will develop a whole-head MEG system for neonates and will demonstrate accurate source localization.

描述(申请人提供)：该项目的目标是开发一种非常低成本的全头新生儿脑磁图系统，可以适应头部的形状和大小。在临床上，长期以来一直需要一种技术来帮助诊断和预后因宫内和出生后中枢神经系统损伤而导致大脑功能障碍的婴儿，这可能会导致智力低下和神经发育障碍。建议的系统是完全非侵入性的，基于原子磁强计技术的最新突破，该技术消除了传统脑磁图系统中使用超导传感器所带来的大部分成本和复杂性。在第一阶段项目中，我们确定并解决了所有主要的技术风险因素，并成功地证明了我们方法的可行性。在第二阶段，我们将为新生儿开发一个全头脑磁图系统，并将展示准确的来源定位。

项目成果

A bi-planar coil system for nulling background magnetic fields in scalp mounted magnetoencephalography.

在头皮安装的磁刻摄影术中用于无效背景磁场的双平面线圈系统。

• DOI: 10.1016/j.neuroimage.2018.07.028
• 发表时间: 2018-11-01
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Holmes N;Leggett J;Boto E;Roberts G;Hill RM;Tierney TM;Shah V;Barnes GR;Brookes MJ;Bowtell R
• 通讯作者: Bowtell R

Moving magnetoencephalography towards real-world applications with a wearable system.

• DOI: 10.1038/nature26147
• 发表时间: 2018-03-29
• 期刊: Nature
• 影响因子: 64.8
• 作者: Boto E;Holmes N;Leggett J;Roberts G;Shah V;Meyer SS;Muñoz LD;Mullinger KJ;Tierney TM;Bestmann S;Barnes GR;Bowtell R;Brookes MJ
• 通讯作者: Brookes MJ