Adjustable Helmet Array for Neonatal Magnetoencephalography

用于新生儿脑磁图的可调头盔阵列

• 批准号: 8791327
• 负责人: Vishal K Shah
• 金额: $ 73.21万
• 依托单位: QUSPIN
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-21 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8791327
• 关键词: Address; Adopted; Adult; Algorithms; Appearance; Area; Automobile Driving; Brain; Calibration; Complex; Computer software; Coupled; Custom; Data; Development; Devices; Diagnosis; Electronics; Elements; Evaluation Reports; Fiber; Financial compensation; Frequencies; Functional Imaging; Functional disorder; Goals; Head; Helmet; Human; Imaging Techniques; Infant; Investments; Lasers; Lead; Light; Magnetism; Magnetoencephalography; Mental Retardation; Metals; Modification; Mus; Neonatal; Neuraxis; Neurodevelopmental Disorder; Noise; Operating System; Output; Patients; Peripheral; Persons; Phase; Positioning Attribute; Price; Research Infrastructure; Research Personnel; Risk; Sales; Shapes; Side; Signal Transduction; Slide; Source; Surface; System; Technology; Temperature; Testing; Universities; Variant; Width; Wisconsin; atomic transition; base; biomagnetism; cost; data acquisition; human subject; magnetic field; neonate; neurodevelopment; outcome forecast; patient safety; postnatal; prototype; public health relevance; sensor; superconducting quantum interference device

DESCRIPTION (provided by applicant): The goal of this project is to develop a very low-cost, whole-head neonatal MEG system that can adapt to the shape and size of the head. Clinically, there is a longstanding need for a technology that can aid in the diagnosis and prognosis of babies with brain dysfunction due to intrauterine and postnatal central nervous system insults, which may result in mental retardation and neurodevelopmental disorders. The proposed system is completely non-invasive and is based on a recent breakthrough in atomic magnetometer technology that eliminates the majority of the costs and complexity associated with the use of superconducting sensors in traditional MEG systems. In the Phase I project, we identified and addressed all major technical risk elements, and successfully demonstrated the viability of our approach. In Phase II we will develop a whole-head MEG system for neonates and will demonstrate accurate source localization.

描述（由申请人提供）：本项目的目标是开发一种非常低成本的、能够适应头部形状和大小的全头部新生儿脑磁图系统。临床上，长期以来一直需要一种技术，可以帮助诊断和预后的婴儿与脑功能障碍，由于宫内和产后中枢神经系统损伤，这可能会导致智力迟钝和神经发育障碍。所提出的系统是完全非侵入性的，并且基于原子磁力计技术的最新突破，该技术消除了与传统MEG系统中使用超导传感器相关的大部分成本和复杂性。在第一阶段项目中，我们识别并解决了所有主要的技术风险因素，并成功证明了我们方法的可行性。在第二阶段，我们将开发一个新生儿全头部MEG系统，并将证明准确的源定位。

项目成果

A bi-planar coil system for nulling background magnetic fields in scalp mounted magnetoencephalography.

在头皮安装的磁刻摄影术中用于无效背景磁场的双平面线圈系统。

• DOI: 10.1016/j.neuroimage.2018.07.028
• 发表时间: 2018-11-01
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Holmes N;Leggett J;Boto E;Roberts G;Hill RM;Tierney TM;Shah V;Barnes GR;Brookes MJ;Bowtell R
• 通讯作者: Bowtell R

Moving magnetoencephalography towards real-world applications with a wearable system.

• DOI: 10.1038/nature26147
• 发表时间: 2018-03-29
• 期刊: Nature
• 影响因子: 64.8
• 作者: Boto E;Holmes N;Leggett J;Roberts G;Shah V;Meyer SS;Muñoz LD;Mullinger KJ;Tierney TM;Bestmann S;Barnes GR;Bowtell R;Brookes MJ
• 通讯作者: Brookes MJ