Liquid chromatography for clinical silicon photonics

这个博士项目旨在基于前沿的硅光子学研究开发一类用于临床诊断的新型传感器。将色谱分析功能添加到我们现有的中红外吸收光谱传感器中，将实现更强大的数据提取。这将为机器学习提供更多信息，以提高临床决策的准确性。该项目将与我们在南安普顿大学医院（UHS）的合作伙伴一起探索这项技术的医疗应用。一个例子是用于癌症诊断的液体活检，其中该方法可以提供癌性和非癌性血液样品之间的改进的区分，而不需要手术活检。该项目将通过设计、制造和测试传感器来研究生物标志物的检测，以监测其独特的光谱吸收指纹，从而了解人类血液样本的组成。微流控色谱将与光子传感器集成，以获得进一步的蛋白质组学和脂质组学信息。

This PhD project aims to develop a new class of sensors for clinical diagnostics based on cutting- edge silicon photonics research. Adding the capability for chromatography to our existing sensors for mid-infrared absorption spectroscopy will enable more powerful data extraction. This will provide more information for machine learning to improve the accuracy of clinical decision-making.The project will explore medical applications for this technique with our partners at University Hospital Southampton (UHS). One example is liquid biopsy for cancer diagnostics in which this method can offer improved discrimination between cancerous and non-cancerous blood samples without the need for a surgical biopsy. The project will investigate detection of biomarkers by designing, fabricating and testing sensors for monitoring their unique spectral absorption fingerprints in order to understand the composition of human blood samples. Microfluidic chromatography will be developed for integration with the photonic sensors to obtain further proteomic and lipidomic information.