Participant Perspectives on Drug Use/HIV Research Ethics

描述（由申请人提供）：研究非法药物使用和相关HIV风险的研究者面临着独特的伦理挑战。中毒、长期吸毒或艾滋病毒/艾滋病晚期都可能损害同意能力。参与购买毒品和诊断艾滋病毒/艾滋病的犯罪活动使参与者特别容易受到违反保密规定的伤害，这可能导致刑事起诉、社会污名化或失业。需要钱购买药物或种族和经济健康差异可能会增加对参与研究的现金或治疗补偿胁迫的敏感性。随机对照试验设计的参与者在排毒过程中可能会出现戒断症状，或者当实验治疗与街头药物相互作用时可能会出现副作用。研究结果的传播可能会进一步污名化或维持对历史上受压迫群体的社会偏见。通过焦点小组、深度访谈和结构化访谈调查，本研究旨在探讨弱势非法吸毒者给研究伦理实践带来的希望、价值观和恐惧。这一合作项目结合了福特汉姆大学伦理教育中心和西班牙裔卫生委员会基于社区的药物滥用和艾滋病毒/艾滋病经验的优势，将深入研究街头吸毒者对研究风险和利益、知情同意、保密以及在药物滥用和艾滋病毒相关风险的流行病学、社会关联和治疗研究中使用奖励的态度。还将审查性别和种族如何影响这些态度。该项目的长期目标是确定经济上处于不利地位、种族多样化的非法街头吸毒者的伦理问题，以反映参与者的价值观和值得信任的方式，为吸毒和艾滋病毒风险研究提供信息和加强研究。

DESCRIPTION (provided by applicant): Investigators studying illicit drug use and related HIV risk face unique ethical challenges. Intoxication, long term drug use, or advanced stages of HIV/AIDS can impair consent capacity. Involvement in criminal activities to purchase drugs and diagnosis of HIV/AIDS make participants especially vulnerable to breaches in confidentiality that may result in criminal prosecution, social stigmatization, or loss of employment. The need for money to purchase drugs or ethnic and economic health disparities may heighten susceptibility to coercion from cash or treatment compensation for research participation. Participants in RCT designs may suffer withdrawal symptoms during detoxification or side effects when experimental treatments interact with street drugs. Dissemination of research results may further stigmatize or sustain societal prejudices against historically oppressed groups. Through focus groups, in-depth interviews, and structured interview surveys, this research aims to explore the hopes, values, and fears that multiply vulnerable illicit drug users bring to research ethics practices. This collaborative project uniting the strengths of the Fordham University Center for Ethics Education and the community based substance abuse and HIV/AIDS experience of the Hispanic Health Council, will examine in both depth and breath the attitudes of street drug users towards research risks and benefits, informed consent, confidentiality, and use of incentives in research on the epidemiology, social correlates, and treatments for drug abuse and HIV related risks. How gender and ethnicity influence these attitudes will also be examined. Long-term goals of this project are to identify ethical concerns among economically disadvantaged, ethnically diverse illicit street drug users that will inform and enhance drug use and HIV risk research in ways that reflect the values and merit the trust of participants.